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|Centuries:||13th century – 14th century – 15th century|
|Decades:||1320s 1330s 1340s – 1350s – 1360s 1370s 1380s|
|Years:||1349 1350 1351 – 1352 – 1353 1354 1355|
- June 4 – Glarus joins the Swiss Confederation.
- June 27 – Zug joins the Swiss Confederation.
- December 18 – Pope Innocent VI succeeds Pope Clement VI as the 199th pope.
- Moroccan traveller Ibn Battuta reports the existence of the ngoni and balafon instruments at the court of Mansa Musa.
- Dragoş becomes voivode of Moldova.
- Corpus Christi College founded as a College of the University of Cambridge by the Guilds of Corpus Christi and the Blessed Virgin Mary.
- The Ottoman Turk army crosses the Bosporus, entering the Balkans.
- Lionel of Antwerp marries Elizabeth, daughter of William de Burgh, 3rd Earl of Ulster.
- William de Ashlee becomes Rector of Maids Moreton, England.
- The town of Biel/Bienne, Switzerland finalizes its alliance with the city of Bern.
- Reginald de Cobham, 1st Baron Cobham becomes a Companion of the Most Noble Order of the Garter of England.
- The Earldom of Kent becomes extinct (see Deaths, below).
- The Metropolitan of the Ukrainian Greek Catholic Church, the Metropolitan of Halych, began to relocate back to Kiev, after having moved to Halych in 1299. Thereafter, the Metropolitan would hold the title of Metropolitan of Kiev-Halych and All Rus.
- John Holland, 1st Duke of Exeter (estimate). (died 1400)
- Vytautas the Great, Grand Duke of Lithuania (died 1430)
- Rupert of Germany, Count Palatine of the Rhine (died 1410)
- July 3 – Archbishop Vasilii Kalika of Novgorod.
- September 15 – Ewostatewos, Ethiopian monk and religious leader (born 1273)
- December 6 – Pope Clement VI (born 1291)
- Matthias of Arras, French architect (born 1290)
- William de Ros, 4th Baron de Ros (born 1325)
- Basarab I, Prince of Wallachia
- Al-Hakim II, Caliph of Cairo
- Laurence Minot, English poet (born 1300)
- Yoshida Kenko, Japanese monk and author (born 1283)