Ferdinando II de' Medici, Grand Duke of Tuscany
Ferdinando II de' Medici (14 July 1610 – 23 May 1670) was Grand Duke of Tuscany from 1621 to 1670. He was the eldest child of Cosimo II de' Medici and Maria Maddalena of Austria. His 49 year rule saw the Medici Bank fail. He married Vittoria della Rovere, with whom he had two children: Cosimo III de' Medici, his eventual successor, and Francesco Maria de' Medici, a Prince of the Church.
- Cosimo de' Medici, Grand Prince of Tuscany (19 December 1639 - 21 December 1639) died in infancy.
- Unnamed son (1640)
- Cosimo III de' Medici, Grand Duke of Tuscany (14 August 1642 – 31 October 1723) married Marguerite Louise d'Orléans and had issue.
- Francesco Maria de' Medici (12 November 1660 – 3 February 1711) married Eleonora Luisa Gonzaga, no issue.