Golden Dart Frog
(Myers, Daly, and Malkin, 1978)
Phyllobates terribilis, the Golden Poison Frog or the Golden Dart Frog, is a poison dart frog endemic to the Pacific coast of Colombia. In captivity, poison dart frogs are not poisonous. It is in the wild where they are poisonous because of what they eat. This amphibian of the Dendrobatidae family is currently considered the most poisonous vertebrate worldwide. The optimal habitat of P. terribilis is the rainforest with high rain rates (5 m. or more), altitude between 100-200 m, temperature of 26 °C, and relative humidity of 80-90%.
- "In a 20-gram white mouse, the minimal lethal dose of batrachotoxin/homobatrachotoxin is about 0.05 µg, when injected subcutaneously. Thus, one frog, P. terribilis, with typical 1100 µg of these compounds, contains enough poison to kill more than 20,000 mice. Although extrapolating toxicity parameters from mouse to man has errors, if we suppose that man is at least as susceptible as mice to these compounds, the lethal dose is about 180 µg for a person. Larger animals are often more susceptible to toxins that smaller organisms, so that the lethal dose for man may be even less. Myers et al.  anticipated a lethal dose of batrachotoxin for man of only 2.0 to 7.5 µg, when administered by injection.
- "The oral potency of batrachotoxin is much lower; therefore, Indians can eat animals captured by their darts without of risk of intoxication. In additions, the small amount of poison used is metabolized and the metabolites are not poisonous; most importantly, cooking may also destroy the toxins, although not all toxins are heat labile".
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