Innate immune system
The innate immune system is the cells and mechanisms which defend the host from infections in a non-specific way.
This means the cells of the innate system recognize and respond to pathogens in a general way, but unlike the adaptive immune system, it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defence against infection, and are found in all plant and animal life.
The vertebrate innate immune system:
- Acts as a physical and chemical barrier to infectious agents. If that fails, then:
- Gets immune cells (such as natural killer cells) to the infection by producing cytokines.
- Starts the complement cascade to identify bacteria, activate cells and clear out dead cells.
- White blood cells identify and remove foreign substances present in organs, tissues, blood and lymph.
- Activates the adaptive immune system through a process known as antigen presentation.
Anatomical barriers [change]
The epithelial surfaces form a physical barrier that keeps out most infectious agents. It is the first line of defence against invading organisms.
Old skin cells drop off, and this helps remove bacteria that have stuck to the skin. In the gastrointestinal and respiratory tract, movement due to peristalsis or cilia helps remove infectious agents. Also, mucus traps infectious agents. The gut flora can prevent pathogenic bacteria by secreting toxic substances or by competing with pathogenic bacteria for nutrients or attachment to cell surfaces. The flushing action of tears and saliva helps prevent infection of the eyes and mouth.
Inflammation is one of the first responses of the immune system to infection or irritation.
Inflammation is stimulated by chemical factors released by injured cells. It serves to establish a physical barrier against the spread of infection, and to promote healing of any damaged tissue after the clearance of pathogens.
Complement system [change]
The cascade is composed of many plasma proteins, synthesized in the liver. The proteins work together to:
- trigger the recruitment of inflammatory cells.
- tag pathogens for destruction by coating their surface.
- disrupt the plasma membrane of an infected cell, resulting in cytolysis of the infected cell, causing the death of the pathogen.
- rid the body of neutralized antigen-antibody complexes.
Cells of the innate immune response [change]
All white blood cells (WBC) are known as leukocytes. Leukocytes are different from other cells of the body: they work like independent, single-celled organisms. They can move freely, and capture cell debris, foreign particles, or invading microorganisms. They are produced by blood-forming stem cells in the bone marrow.
The innate leukocytes include: Natural killer cells, mast cells, eosinophils, basophils; and the phagocytic cells including macrophages, neutrophils and dendritic cells. They identify and eliminate pathogens that cause infection.
Mast cells [change]
Mast cells are a type of innate immune cell in connective tissue and the mucous membranes. They are intimately associated with defence against pathogens and wound healing. They are also often associated with allergy and anaphylaxis. When activated, mast cells rapidly release characteristic granules, rich in histamine and heparin, along with various hormonal mediators, and chemotactic cytokines into the environment. Histamine dilates blood vessels, causing the signs of inflammation, and recruits neutrophils and macrophages.
The word 'phagocyte' literally means 'eating cell'. These are immune cells that engulf, i.e. phagocytose, pathogens or particles. To engulf a particle or pathogen, a phagocyte extends portions of its plasma membrane, wrapping the membrane around the particle until it is enveloped (i.e. the particle is now inside the cell). Once inside the cell, the invading pathogen is contained inside an endosome which merges with a lysosome. The lysosome contains enzymes and acids that kill and digest the particle or organism. Phagocytes generally patrol the body searching for pathogens, but are also able to react to a group of highly specialized molecular signals produced by other cells, called cytokines. The phagocytic cells of the immune system include macrophages], neutrophils, and dendritic cells.
Phagocytosis of the hosts’ own cells is common as part of regular tissue development and maintenance. When host cells die, phagocytic cells remove them from the affected site. By removing dead cells, phagocytosis is an important part of the healing process.
Macrophages are large phagocytic leukocytes. They can move across the cell membrane of capillary vessels and go between cells to hunt invading pathogens. Macrophages are the most efficient phagocytes, and can phagocytose substantial numbers of bacteria or other cells or microbes. The binding of bacterial molecules to receptors on the surface of a macrophage triggers it to engulf and destroy the bacteria. Pathogens also stimulate the macrophage to produce chemokines, which summon other cells to the site of infection.
Neutrophils and two other cell types (eosinophils and basophils), are known as granulocytes (because they have granules in their cytoplasm) or polymorphonuclear cells (PMNs) due to their distinctive lobed nuclei.
Neutrophil granules contain a variety of toxic substances that kill or inhibit growth of bacteria and fungi. The main products of the neutrophil are strong oxidizing agents. These include hydrogen peroxide, free oxygen radicals and hypochlorite. Neutrophils are the most abundant type of phagocyte, with 50 to 60% of the total circulating leukocytes. They are usually the first cells to arrive at the site of an infection. The bone marrow of a normal healthy adult produces more than 100 billion neutrophils per day, and more than 10 times that many per day during acute inflammation.
Dendritic cells [change]
Dendritic cells (DC) are phagocytic cells present in tissues that are in contact with the external environment, mainly the skin (where they are often called Langerhans cells), and the inner mucosal lining of the nose, lungs, stomach and intestines. Dendritic cells are very important in the process of antigen presentation, and serve as a link between the innate and adaptive immune systems.
Basophils and eosinophils [change]
Basophils and eosinophils are cells related to the neutrophil (see above). When activated by a pathogen encounter, basophils releasing histamine are important in defense against parasites, and play a role in allergic reactions (such as asthma). When they are activated, eosinophils secrete a range of highly toxic proteins and free radicals that kill bacteria and parasites. The same chemicals also cause tissue damage during allergic reactions. Activation and toxin release by eosinophils is therefore tightly regulated to prevent any inappropriate tissue destruction.
Natural killer cells [change]
Natural killer cells, or NK cells, are a part of the innate immune system which does not directly attack invading microbes. Instead, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells. It recognises such cells by a condition known as "missing self". This term describes cells with low levels of a cell-surface marker called MHC I (major histocompatibility complex). This can occur in viral infections of host cells. They were named "natural killer" because they do not require activation in order to kill cells that are "missing self".
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