Larkana or Larkano (لاڑکانہ) is city of Sindh Province, Pakistan. The city is the capital of Larkana District. In August 2000 Larkana celebrated its hundred years of existence. It is located on the south bank of the Ghar canal, 40 miles south of Shikarpur town, and 36 north-east of Mehar.
During British rule Larkana became headquarters of Larkana District and Larkana Taluka – and for a time was part of the Bombay Presidency of British India. Also the North-Western Railway passed through the town. The population according to the 1901 census was 14,543.
Sindhi is the main language but Siraikis, a dialect of Sindhi which is similar to the Sindhi language, is also spoken. Sindhi and English are the official languages.