Latent autoimmune diabetes
||The English used in this article may not be easy for everybody to understand. (February 2012)|
Latent autoimmune diabetes of adults (LADA) is very similar to both Type 1 diabetes and Type 2 diabetes: although the disease is autoimmune, insulin resistance accompanies the disease as it does Type 2 diabetes.
Most latent autoimmune diabetic people are thin, although there are many people that are overweight to slightly obese who have the LADA. The differences between LADA and true type 2 diabetes is, unlike many with the latter, those with LADA become insulin dependent within 3-12 years based on different sources. Latent autoimmune diabetes of adults is very different from true type 1 diabetes in that the condition happens gradually instead of rapid; it's different from type 2 diabetes in that although the latter, like LADA, occurs gradually, with latent autoimmune diabetes of adults, there is also autoimmunity associated.
People with LADA are misdiagnosed as having Type 2 diabetes, except that LADA has GAD antibodies. Contrary to the popular belief, some people with latent autoimmune diabetes do have family histories of Type 2 diabetes involving their parents, sister, brother, uncles, aunts, cousins, etc. Also, LADA does not affect children and teenagers[source?] and usually affects people age 35 and older, but can affect anyone between 23-30 years of age.
Prognosis and treatment[change | change source]
People with LADA usually control their diabetes using very similar methods and changes of lifestyle to Type 2 diabetes: eating right, exercising and oral medications; weight loss is optional. Unlike Type 2 diabetics who might never need to inject insulin, however, the LADA patients become insulin dependent within several years. By contrast only 20% to 30% of those with Type 2 diabetes eventually become insulin dependent (i.e., inject insulin).
Genes and antibodies[change | change source]
There are glutamic acid decarboxylase (GAD) antibodies connected with the latent autoimmune diabetes. There are also TCF7L2 genes associated with Type 2 diabetes which are also connected with LADA.
Complications[change | change source]
References[change | change source]
- Jenny (12 May 2008). "The LADA Epidemic. What's Going on Here?". http://diabetesupdate.blogspot.com/2008/05/lada-epidemic-whats-going-on-here.html. Retrieved 1 December 2009.[unreliable source?]
- LADA/Insulin Resistance . Diabetes Health. Report. Retrieved on April 10, 2010.
- "Latent Autoimmune Diabetes in Adults". Endocrine Regulations. http://www.aepress.sk/endo/full/er0301e.pdf. Retrieved Jan 26, 2010.
- "Latent Autoimmune Diabetes of Adults". American Diabetes Association. http://care.diabetesjournals.org/content/32/2/245.full. Retrieved Jan. 26, 2010.
- "What is LADA". http://ki.se/ki/jsp/polopoly.jsp?d=27869&a=73748&l=en. Retrieved 22 November 2009.
- Dunn, J. P.; Perkins, J. M.; Jagasia, S. M. (2008). "Latent Autoimmune Diabetes in Adults and Pregnancy: Foretelling the Future". Clinical Diabetes 26: 44. doi:10.2337/diaclin.26.1.44.
- Family History and LADA . PubMed. Report. Retrieved on Jan 23, 2010.
- LADA: A Little Known Type of Diabetes . Pharmacy Times. Report. Retrieved on January 27, 2010.
- "LADA". Action LADA. http://www.actionlada.org. Retrieved April 22, 2010.
- "What is LADA". Blood Sugar 101. http://www.phlaunt.com/diabetes/18382053.php. Retrieved Sunday, November 22, 2009.