Oliver Smithies
| Oliver Smithies | |
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 Smithies at the Lindau Nobel Laureate Meeting in 2010
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| Born | June 23, 1925 Halifax, West Riding of Yorkshire, England |
| Nationality | British, American |
| Fields | Biochemistry, genetics |
| Institutions | University of Toronto University of Wisconsin–Madison University of North Carolina at Chapel Hill |
| Alma mater | Balliol College, University of Oxford |
| Known for | Gel electrophoresis, gene targeting |
| Notable awards | Nobel Prize in Physiology or Medicine (2007) |
Oliver Smithies (born Halifax, West Yorkshire, 23 June 1925) is a British-American geneticist and Nobel laureate,[1]
He invented gel electrophoresis in 1955,[2] which is now one of the basic techniques of biochemistry and molecular biology.
Much later, he worked on the technique of homologous recombination of transgenic DNA with genomic DNA. This is the most reliable method of altering animal genomes at present, and the technique behind gene targeting and knockout mice.
Martin Evans and Mario Capecchi were also working on this idea, and they were jointly awarded the Nobel Prize in Physiology or Medicine for 2007.
References[change]
- ↑ "The Nobel Prize in Physiology or Medicine 2007". The Nobel Foundation. http://nobelprize.org/nobel_prizes/medicine/laureates/2007/index.html. Retrieved 2007-10-08.
- ↑ Smithies, Oliver (1955-12). "Zone electrophoresis in starch gels: group variations in the serum proteins of normal human adults". The Biochemical Journal 61 (4): 629–641. ISSN 0264-6021. PMC 1215845. PMID 13276348. http://www.ncbi.nlm.nih.gov/pubmed/13276348. Retrieved 2009-08-04.
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