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THC is the chemical in cannabis that causes the high. It is almost impossible to overdose with as you would have to smoke 1500 pounds (680 kilograms) of cannabis within 15 minutes. [1]

References[change | change source]

  1. Reefer madness-The Federal response to California’s Medical-Marijuana Law.Annas, G.J.  ; New Eng J Med, 1997; 337: 435-439