Alejandro Orfila (born 9 March 1925) is an Argentine retired diplomat. He was born in Mendoza, Argentina. He was the Secretary General of the Organization of American States from 1975 to 1984 replacing Galo Plazas, an Ecuadorian President.
He was an active figure in United States foreign policies dealing with South American. He was a key figure in the Panama Canal Treaty formation. He was present when President Jimmy Carter signed the treaty in 1977. He worked with Carter to fight human rights abuses in the continent.
In 1984, he was replaced with Brazilian diplomat João Clemente Baena Soares.