In 1492, Christopher Columbus discovered The Americas. This is how the Europeans learned that North America and South America were there. The Europeans colonized the Americas. Because of this, and the killing of lots of Native Americans, most people now living in North America are the descendents of Europeans.
Sometimes, science fiction stories talk about humans colonizing outer space on space stations or planets other than Earth. Some science fiction stories like The Matrix speak of the robots the human beings made, taking over, and colonizing Earth.