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The IC50 is a measure of how effective a drug is. It indicates how much of a particular drug or other substance is needed to inhibit a given biological process (or component of a process, i.e. an enzyme, cell, cell receptor or microorganism) by half. In other words, it is the half minimal (50%) inhibitory concentration (IC) of a substance (50% IC, or IC50). It is commonly used as a measure of antagonist drug potency in pharmacological research. Sometimes, it is also converted to the pIC50 scale (-log IC50), in which higher values indicate exponentially greater potency. According to the FDA, IC50 represents the concentration of a drug that is required for 50% inhibition in vitro.[1] It is comparable to an EC50 for agonist drugs. EC50 also represents the plasma concentration required for obtaining 50% of a maximum effect in vivo.[1]

References[change | change source]

  1. 1.0 1.1 "IC50 versus EC50". Food and Drug Administration. Archived from the original on 2011-02-06. Retrieved 2008-02-11.