John Yorke Denham (born July 15, 1953) is an English politician. He is the Member of Parliament for the Southampton Itchen constituency in the United Kingdom. He was first elected in the 1992 general election.
He has held many ministerial posts, including
- 1995-1997 - Opposition Spokesman for Social Security
- 1997-1998 - Parliamentary under Secretary of State at the Department of Social Security
- 1998-1999 - Minister of State at the Department of Social Security
- 1999-2001 - Minister of State for Health Services
- 2001-2003 - Minister of State for Policing
- 2003-2007 - Chairman of the Home Affairs Select Committee
- 2007-2009 - Secretary of State for Innovation, Universities and Skills
- 2009-2010 - Secretary of State for Communities and Local Government
- 2010–present - Shadow Secretary of State for Business, Innovation and Skills
He is a member of the Labour Party.