Louise Jefferson is a fictional character in the American situation comedy All in the Family and its spin-off The Jeffersons. She is played by actress Isabel Sanford. Louise is the wife of George Jefferson. They have a son named Lionel. Louise and her family are neighbors with Archie Bunker and his family. She is good friends with Edith Bunker. She and her husband own a cleaning business and they move to the East Side of Manhattan where the sitcom The Jeffersons takes place.