mTOR is a protein, an enzyme which regulates cell growth, cell division, cell movement, cell survival, protein synthesis, autophagy, and transcription. It is a protein that in humans is encoded by the MTOR gene.
It has been given various names. It was originally called the 'mammalian target of rapamycin', but is also known as the 'mechanistic target of rapamycin' and 'FK506-binding protein 12-rapamycin-associated protein 1' (FRAP1).
The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain.
References[change | change source]
- Hay N & Sonenberg N. 2004. "Upstream and downstream of mTOR". Genes & Development. 18 (16): 1926–45. doi:10.1101/gad.1212704. PMID 15314020. Vancouver style error: punctuation (help)
- Brown E.J. et al 1994. "A mammalian protein targeted by G1-arresting rapamycin-receptor complex". Nature. 369 (6483): 756–8. doi:10.1038/369756a0. PMID 8008069.
- Moore PA; Rosen CA & Carter K.C. 1996. "Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization". Genomics. 33 (2): 331–2. doi:10.1006/geno.1996.0206. PMID 8660990. Vancouver style error: punctuation (help)
- Betz C & Hall M.N. 2013. "Where is mTOR and what is it doing there?". Journal of Cell Biology. 203 (4): 563–74. doi:10.1083/jcb.201306041. PMID 24385483. Vancouver style error: punctuation (help)