mTOR

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mTOR is a protein, an enzyme which regulates cell growth, cell division, cell movement, cell survival, protein synthesis, autophagy, and transcription.[1] It is a protein that in humans is encoded by the MTOR gene.[2][3]

It has been given various names. It was originally called the 'mammalian target of rapamycin', but is also known as the 'mechanistic target of rapamycin' and 'FK506-binding protein 12-rapamycin-associated protein 1' (FRAP1).

The mTOR pathway is a central regulator of mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain.[4]

References[change | change source]

  1. Hay N. & Sonenberg N. 2004. "Upstream and downstream of mTOR". Genes & Development 18 (16): 1926–45. doi:10.1101/gad.1212704. PMID 15314020. 
  2. Brown E.J. et al 1994. "A mammalian protein targeted by G1-arresting rapamycin-receptor complex". Nature 369 (6483): 756–8. doi:10.1038/369756a0. PMID 8008069. 
  3. Moore P.A; Rosen C.A. & Carter K.C. 1996. "Assignment of the human FKBP12-rapamycin-associated protein (FRAP) gene to chromosome 1p36 by fluorescence in situ hybridization". Genomics 33 (2): 331–2. doi:10.1006/geno.1996.0206. PMID 8660990. 
  4. Betz C. & Hall M.N. 2013. "Where is mTOR and what is it doing there?". Journal of Cell Biology 203 (4): 563–74. doi:10.1083/jcb.201306041. PMID 24385483.