Jump to content


From Simple English Wikipedia, the free encyclopedia
The structure of hemoglobin. The haeme cofactor, containing iron, shown in green.

A metalloprotein is a protein that contains a metal ion cofactor.[1] A large fraction of all proteins are members of this category, so the number is very large.

It is estimated that about half of all proteins contain a metal.[2] In another estimate, about one-quarter to one-third of all proteins need metals to carry out their functions.[3] Thus, metalloproteins have many different functions in cells, such as enzymes, transport and storage proteins, and signal transduction proteins.

References[change | change source]

  1. Shriver, D.F; Atkins P.W. (1999). "Chapter 19, Bioinorganic chemistry". Inorganic chemistry (3rd ed.). Oxford University Press. ISBN 0-19-850330-X.
  2. Thomson A.J. & Gray H.B. 1998. "Bio-inorganic chemistry". Current Opinion in Chemical Biology. 2, 155-158. doi:10.1016/S1367-5931(98)80056-2
  3. Waldron K.J. & Robinson N.J (2009). "How do bacterial cells ensure that metalloproteins get the correct metal?". Nat. Rev. Microbiol. 7 (1): 25–35. doi:10.1038/nrmicro2057. PMID 19079350. S2CID 7253420.