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From Simple English Wikipedia, the free encyclopedia

Metroprolol (brand names Lopressor and Toprol XL) is a beta blocker medication used to:[1]

Clinical data
Pronunciation/mɛˈtprlɑːl/, /mɛtˈprlɑːl/
Trade namesLopressor, Metolar XR, Toprol XL, others
License data
  • AU: C
Routes of
By mouth, intravenous
Drug classBeta blocker
ATC code
Pharmacokinetic data
Bioavailability50% (single dose)[2]
70% (repeated administration)[3]
Protein binding12%
MetabolismLiver via CYP2D6, CYP3A4
Elimination half-life3–7 hours
CAS Number
PubChem CID
ECHA InfoCard100.051.952 Edit this at Wikidata
Chemical and physical data
ChiralityRacemic mixture

Metoprolol was first made in 1969, patented in 1970, and approved for medical use in 1978.[4][5][6] It is on the World Health Organization's List of Essential Medicines.[7] It is available as a generic medication.[8] In 2021, it was the sixth most commonly prescribed medication in the United States, with more than 65 million prescriptions.[9][10][11]

Metoprolol is only available on prescription and it comes as tablets. It can also be given by injection, but this is usually done in hospital.[1]

Related pages[change | change source]

References[change | change source]

  1. 1.0 1.1 "Metoprolol: medicine for high blood pressure (hypertension)". nhs.uk. 2022-03-15. Retrieved 2024-06-03.
  2. "Metolar 25/50 (metoprolol tartrate) tablet" (PDF). U.S. Food and Drug Administration (FDA). Archived (PDF) from the original on 3 March 2016. Retrieved 5 May 2015.
  3. Jasek W, ed. (2007). Austria-Codex (in German) (62nd ed.). Vienna: Österreichischer Apothekerverlag. pp. 916–919. ISBN 978-3852001814.
  4. "Lopressor: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 20 June 2023.
  5. Carlsson B, ed. (1997). Technological systems and industrial dynamics. Dordrecht: Kluwer Academic. p. 106. ISBN 978-0792399728. Archived from the original on 3 March 2017.
  6. Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 461. ISBN 978-3527607495.
  7. World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  8. "Metoprolol". The American Society of Health-System Pharmacists. Archived from the original on 12 March 2014. Retrieved 21 April 2014.
  9. "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  10. "Metoprolol – Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  11. Source Wikipedia