NCIS can refer to:
- Naval Criminal Investigative Service - Primary law enforcement agency of the United States Department of the Navy
- NCIS (TV series) - A crime-drama television series on CBS
- NCIS: Los Angeles - A crime-drama television series set in Los Angeles. Spin-off of NCIS TV series
- NCIS: New Orleans - American military crime-drama set in New Orleans. Spin-off of NCIS TV series
- National Crop Insurance Service - A nonprofit organization that represents private crop insurance companies
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