Pharmacodynamics

Topics of pharmacodynamics

Pharmacodynamics (PD) is the study of how a drug affects a living thing (like a person, animal, or tiny organism). It looks at the changes—both chemical and physical—that happen in the body because of the drug.

Pharmacodynamics is one of the two main parts of pharmacology (the study of drugs). The other main part is pharmacokinetics (PK), which studies how the living thing affects the drug (like how the body absorbs, breaks down, and gets rid of the drug).

Together, PD and PK help us figure out the right dose of a medicine, how much good it will do, and what its bad effects might be.

Basics

Pharmacodynamics especially focuses on the dose-response relationship. This is how the drug's amount (concentration) in the body leads to a specific effect.

Drugs work by interacting with four main types of proteins in the body:

Main Drug Target Categories in Pharmacodynamics

Protein Target	What it Does (Function)	Examples of Drug Actions
Enzymes	Speed up or slow down chemical reactions in the body.	Inhibitors block them; Inducers make them work faster.
Membrane Carriers	Move substances (like neurotransmitters) into or out of cells across the cell membrane.	Inhibitors block the movement (e.g., reuptake inhibitors); Releasers cause the substance to be let out.
Ion Channels	Act like tiny gates to let charged particles (ions) into or out of cells, changing the cell's electrical activity.	Blockers shut the gate; Openers open it.
Receptors	Receive signals (like from hormones or neurotransmitters) and cause a specific response inside the cell.	Agonists activate them (mimic the signal); Antagonists block them (stop the signal).

Effects on the body

Drugs usually work in one of these ways:

1. Mimic (copy) or stop (inhibit) normal processes in the body.
2. Stop vital processes in tiny harmful organisms like bacteria or parasites.

There are seven main actions of a drug:

1. Stimulating: Making a process work faster or stronger (like an agonist).
2. Depressing: Making a process work slower or weaker.
3. Blocking/Antagonizing: Attaching to a target and stopping it from being activated.
4. Stabilizing: Keeping the system balanced, acting as neither a strong stimulant nor depressant (this depends on the dose).
5. Exchanging/Replacing: Giving the body something it is missing (like insulin for diabetes).
6. Direct Chemical Reaction: Causing a beneficial chemical change (like an antioxidant).
7. Direct Harmful Chemical Reaction: Causing damage or death to cells (called cytotoxicity).

Desired activity

The good effect of a drug is often achieved by successfully targeting one of these:

• Receptors: The largest group of drugs bind to receptors to cause or block a cell response.
• Enzymes: Drugs like aspirin stop an enzyme from creating the chemicals that cause swelling (inflammation).
• Carrier Proteins: Drugs can stop a carrier from pumping substances in or out of a cell.

Undesirable effects

Drugs can also have bad effects, such as:

• Causing many different actions at once that are harmful.
• Making the person need a larger dose over time (development of tolerance).
• Causing long-term problems or cell damage.

Therapeutic window

The therapeutic window is the range of drug dose that is high enough to work but low enough to avoid major bad effects.

A drug with a small window must be given very carefully, as it's easy to accidentally give too little (no effect) or too much (toxic effect).

Duration of action

The duration of action is the total time a drug is effective. It depends on how quickly the drug is broken down, removed from the body, and how strongly it stays attached to its target.

Receptor binding and effect

A drug must first bind to a receptor to have an effect. This is usually explained by a simple chemical equation:

${\ce {L + R <=> LR}}$

• L is the drug (or ligand).
• R is the receptor.
• LR is the drug attached to the receptor.

The effect of the drug is related to the fraction of bound receptors (how many are occupied).

Receptor Reserve: This is when a drug can cause the maximum possible effect in a cell even if it only binds to a small fraction of the total receptors. It means the cell has more receptors than it needs for a full response.

Multicellular pharmacodynamics

Multicellular Pharmacodynamics (MCPD) is a newer, more complex area of study. It looks at how a drug affects a whole group of interacting cells or a small, complete living system, rather than just looking at one drug and one cell target.

Toxicodynamics

Toxicodynamics (TD) is very similar to pharmacodynamics, but it focuses on the harmful effects of a drug, poison, or toxic substance.

• TD looks at how much of a toxic substance is present and the kind of damage it causes.
• Most bad side effects are dose-dependent (Type A), meaning more drug causes more bad effect.
• Some bad effects are idiosyncratic (Type B), meaning they are not dose-dependent and might be caused by a strange reaction (like an allergy).

Toxicodynamics and pharmacodynamics are sometimes called toxicokinetics and toxicodynamics in the study of harmful effects on the environment (ecotoxicology).