Propylene glycol

Propylene glycol^[1]
ball-and-stick model	Space-filling model
Names
	Preferred IUPAC name Propane-1,2-diol
	Other names Propylene glycol; α-Propylene glycol; 1,2-Propanediol; 1,2-Dihydroxypropane; Methyl ethyl glycol; Methylethylene glycol; PEG;
Identifiers
CAS Number	57-55-6 racemic ; 4254-15-3 S-enantiomer;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:16997 ;
ChEMBL	ChEMBL286398 ;
ChemSpider	13835224 ;
ECHA InfoCard	100.000.307
EC Number	200-338-0;
E number	E1520 (additional chemicals)
KEGG	C00583;
PubChem CID	1030;
RTECS number	TY6300000;
UNII	6DC9Q167V3 ; 942194N4TD (S-enantiomer) ;
CompTox Dashboard (EPA)	DTXSID0021206 ;
	SMILES CC(O)CO;
Properties
Chemical formula	C3H8O2
Molar mass	76.10 g·mol−1
Appearance	colourless liquid
Odor	odorless
Density	1.036 g/cm3
Melting point	−59 °C (−74 °F; 214 K)
Boiling point	188.2 °C (370.8 °F; 461.3 K)
Solubility in water	Miscible
Solubility in ethanol	Miscible
Solubility in diethyl ether	Miscible
Solubility in acetone	Miscible
Solubility in chloroform	Miscible
log P	−1.34
Vapor pressure	10.66 Pa (20 °C)
Thermal conductivity	0.34 W/m·K (50% H2O @ 90 °C (194 °F))
Viscosity	0.042 Pa·s
Thermochemistry
Specific heat capacity, C	189.9 J/(mol·K)
Pharmacology
ATCvet code	QA16QA01 (WHO)
Hazards
	GHS labelling:
Hazard statements	Template:HPhrases
Precautionary statements	Template:PPhrases
NFPA 704 (fire diamond)	0 1 0
Related compounds
Related glycols	Ethylene glycol, 1,3-propanediol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Propylene glycol, also called 1,2-propanediol or α-propylene glycol, is an organic compound. The chemical formula of propylene glycol is CH₃CH(OH)CH₂OH. Propylene glycol is used as a food additive, an ingredient in polymers, and a solvent. Mixtures of propylene glycol and water are used as antifreeze.^[6] It is mixed with glycerin to make liquid for e-cigarettes.^[7]

It is the second-simplest vicinal diol, a type of chemical where two hydroxy groups are attached to a pair of neighbouring carbon atoms. It is a positional isomer of trimethylene glycol, which is sometimes also called β-propylene glycol.

Sources

↑ The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. Merck & Co. 1989. ISBN 978-0-911910-28-5.
↑ "Propylene Glycol_msds".
↑ Zaripov, Z.I. (1982). Experimental study of the isobaric heat capacity of liquid organic compounds with molecular weights of up to 4000 a.e.m.
↑ GHS: "Kein gefährlicher Stoff nach GHS" GESTIS 013620
"Propylene Glycol - Cameo Chemicals". NOAA Office of Response and Restoration. NOAA. Retrieved 3 October 2018.
↑ Freeman, Andrew I.; Surridge, Ben W.J.; Matthews, Mike; Stewart, Mark; Haygarth, Philip M. (2015). "Understanding and managing de-icer contamination of airport surface waters: A synthesis and future perspectives". Environmental Technology & Innovation. 3: 46–62. Bibcode:2015EnvTI...3...46F. doi:10.1016/j.eti.2015.01.001.
↑ Carpenter, Matthew J.; Cummings, K Michael; Wahlquist, Amy E.; Heckman, Bryan W.; Smith, Tracy T. (2020). "The Impact of E-liquid Propylene Glycol and Vegetable Glycerin Ratio on Ratings of Subjective Effects, Reinforcement Value, and Use in Current Smokers". Nicotine & Tobacco Research. 22 (5): 791–797. doi:10.1093/ntr/ntz130. PMC 7171278. PMID 31403695.

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[1] The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals. Merck & Co. 1989. ISBN 978-0-911910-28-5.

[chemsrc-2] "Propylene Glycol_msds".

[3] Zaripov, Z.I. (1982). Experimental study of the isobaric heat capacity of liquid organic compounds with molecular weights of up to 4000 a.e.m.

[4] GHS: "Kein gefährlicher Stoff nach GHS" GESTIS 013620

[5] "Propylene Glycol - Cameo Chemicals". NOAA Office of Response and Restoration. NOAA. Retrieved 3 October 2018.

[6] Freeman, Andrew I.; Surridge, Ben W.J.; Matthews, Mike; Stewart, Mark; Haygarth, Philip M. (2015). "Understanding and managing de-icer contamination of airport surface waters: A synthesis and future perspectives". Environmental Technology & Innovation. 3: 46–62. Bibcode:2015EnvTI...3...46F. doi:10.1016/j.eti.2015.01.001.

[7] Carpenter, Matthew J.; Cummings, K Michael; Wahlquist, Amy E.; Heckman, Bryan W.; Smith, Tracy T. (2020). "The Impact of E-liquid Propylene Glycol and Vegetable Glycerin Ratio on Ratings of Subjective Effects, Reinforcement Value, and Use in Current Smokers". Nicotine & Tobacco Research. 22 (5): 791–797. doi:10.1093/ntr/ntz130. PMC 7171278. PMID 31403695.

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