Secretin

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Secretin is a peptide hormone that regulates water balance throughout the body. It is produced in secretory glands of the duodenum.[1] In humans, the secretin peptide is encoded by the SCT gene, which sits on chromosome 11.[2]

In 2007, secretin was discovered to play a role in osmoregulation by acting on the hypothalamus, pituitary gland, and kidney.[3][4]

Secretin was the first hormone to be identified.[5] The crucial experiments were done at University College London in 1902. The term 'hormone' was invented in 1905.[6]

References[change | change source]

  1. Häcki WH (1980). "Secretin". Clinics in Gastroenterology 9 (3): 609–32. PMID 7000396. 
  2. Kopin AS, Wheeler MB, Leiter AB (1990). "Secretin: structure of the precursor and tissue distribution of the mRNA". Proceedings of the National Academy of Sciences of the United States of America 87 (6): 2299–303. doi:10.1073/pnas.87.6.2299. PMC 53674. PMID 2315322. 
  3. Chu JY et al (2007). "Phenotypes developed in secretin receptor-null mice indicated a role for secretin in regulating renal water reabsorption". Molecular and Cellular Biology 27 (7): 2499–511. doi:10.1128/MCB.01088-06. PMC 1899889. PMID 17283064. 
  4. Chu J.Y. et al (2009). "Secretin as a neurohypophysial factor regulating body water homeostasis". Proceedings of the National Academy of Sciences of the United States of America 106 (37): 15961–6. doi:10.1073/pnas.0903695106. PMC 2747226. PMID 19805236. 
  5. Henriksen JH, Schaffalitzky de Muckadell OB (2002). "Sekretin - det første hormon" (in Danish). Ugeskrift for Laeger 164 (3): 320–5. PMID 11816326. 
  6. Hirst, BH (2004), "Secretin and the exposition of hormonal control", J Physiol, 560: 339, PMID 15308687