Sirtuin

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Sirtuin or Sir2 proteins are a class of enzymes that are important in cell biology.[1][2][3][4][5]

Sirtuins regulate important biological pathways in bacteria, archaea and eukaryotes. The name Sir2 comes from the yeast gene 'silent mating-type information regulation 2',[6] the gene responsible for cellular regulation in yeast.

Sirtuins influence many cellular processes like ageing, transcription, apoptosis, inflammation and stress resistance,[7] as well as energy efficiency and alertness during low-calorie situations.[8] Sirtuins can also control circadian clocks and mitochondrial biogenesis.

References[change | change source]

  1. North B.J. & Verdin E. 2004. "Sirtuins: Sir2-related NAD-dependent protein deacetylases". Genome Biology 5 (5): 224. doi:10.1186/gb-2004-5-5-224. PMC 416462. PMID 15128440. 
  2. Yamamoto H; Schoonjans K. & Auwerx J. 2007. "Sirtuin functions in health and disease". Mol. Endocrinol. 21 (8): 1745–55. doi:10.1210/me.2007-0079. PMID 17456799. 
  3. Du J. et al 2011. "Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.". Science 334 (6057): 806–809. doi:10.1126/science.1207861. PMC 3217313. PMID 22076378. 
  4. Jiang H. et al 2013. "SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.". Nature 496 (7443): 110–113. doi:10.1038/nature12038. PMC 3635073. PMID 23552949. 
  5. Rack J.G.M. et al 2015. "Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens". Molecular Cell 59 (2): 309–320. doi:10.1016/j.molcel.2015.06.013. ISSN 1097-4164. PMC 4518038. PMID 26166706. https://www.ncbi.nlm.nih.gov/pubmed/26166706. 
  6. EntrezGene 23410 [1]
  7. Preyat N. & Leo O. 2013. "Sirtuin deacylases: a molecular link between metabolism and immunity.". J. Leuk. Biol. 93 (5): 669–680. doi:10.1189/jlb.1112557. PMID 23325925. 
  8. Satoh A. et al 2010. "SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus.". Journal of Neuroscience 30 (30): 10220–32. doi:10.1523/JNEUROSCI.1385-10.2010. PMC 2922851. PMID 20668205.