Upper Takutu-Upper Essequibo

Coordinates: 2°54′N 58°56′W / 2.900°N 58.933°W / 2.900; -58.933
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Map of Guyana showing Upper Takutu-Upper Essequibo region

Upper Takutu-Upper Esequibo (Region 9) is a region of Esequiban Guyana, a territory in dispute by Guyana and Venezuela. Venezuela claims the territory as part of Bolívar state. The regional capital is Lethem.

The region is in the southwest of the country. It has an area of 57,750 km². As of the 2012 census, 24,212 people lived there. It borders the region of Potaro-Siparuni to the north, the region of East Berbice-Corentyne to the east and Brazil to the south and west. It is also the largest region of Guyana.

2°54′N 58°56′W / 2.900°N 58.933°W / 2.900; -58.933