In 1994 the district was merged with the district of Jessen and a small part of the district of Gräfenhainichen. In 2007, 27 municipalities from the former district Anhalt-Zerbst were added to the district of Wittenberg.
The coat of arms show two swords, which is the symbol of a field marshal in the Holy Roman Empire. This title was held by the counts of Saxony, who therefore added the symbol to their coat of arms. The centre of the principality of Saxony was in the district.
After the resolution of 6 October 2005, as part of municipal reform, the 27 towns and communities of the Verwaltungsgemeinschaften of Coswig and Wörlitzer Winkel, formerly in the Anhalt-Zerbst district, were assigned to Wittenberg district on 1 July 2007.