Warfarin

Warfarin
Clinical data
Pronunciation	/ˈwɔːrfərɪn/
Trade names	Coumadin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a682277
License data	US DailyMed: Warfarin;
Pregnancy; category	AU: D; ;
Routes of; administration	By mouth, intravenous
ATC code	B01AA03 (WHO) QB01AA03 (WHO);
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	79–100% (by mouth)
Protein binding	99%
Metabolism	Liver: CYP2C9, 2C19, 2C8, 2C18, 1A2 and 3A4
Elimination half-life	1 week (active half-life is 20-60 hours)
Excretion	Kidney (92%)
Identifiers
CAS Number	81-81-2 ; as salt: 129-06-6;
PubChem CID	54678486; as salt: 16204922;
IUPHAR/BPS	6853;
DrugBank	DB00682 ; as salt: DBSALT000278;
ChemSpider	10442445 ; as salt: 17333193;
UNII	5Q7ZVV76EI; as salt: 6153CWM0CL;
KEGG	D08682 ; as salt: D00564;
ChEBI	CHEBI:10033 ; as salt: CHEBI:10034;
ChEMBL	ChEMBL1464 ; as salt: ChEMBL1200879;
PDB ligand	RWF (PDBe, RCSB PDB); as salt: SWF (PDBe, RCSB PDB);
ECHA InfoCard	100.001.253
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Warfarin (brand names Coumadin and Jantoven) is a powerful water-soluble compound. It prevents blood from clotting.

It works by reducing the production of factors by the liver that promote clotting. It is called an "anticoagulant agent". It is a powerful rat poison. In concentrated form, it causes bleeding of internal organs which leads to death.^[8]

It is also used, in very low doses, to prevent thrombosis in humans.^[9] This is the local coagulation or clotting of the blood in the circulatory system. In such cases, it makes heart attacks, strokes, and pulmonary embolism less likely.^[9] The degree of anticoagulation is monitored by blood tests.

Warfarin has also been used in pest control.

Related pages[change | change source]

References[change | change source]

↑ "Warfarin Use During Pregnancy". Drugs.com. 4 September 2019. Archived from the original on 9 February 2018. Retrieved 7 February 2020.
↑ Cite error: The named reference brands was used but no text was provided for refs named (see the help page).
↑ Cite error: The named reference brands2 was used but no text was provided for refs named (see the help page).
↑ Cite error: The named reference brands3 was used but no text was provided for refs named (see the help page).
↑ "Coumadin- warfarin sodium tablet". DailyMed. Archived from the original on 26 December 2021. Retrieved 25 December 2021.
↑ ^6.0 ^6.1 ^6.2 ^6.3 Cite error: The named reference TGA was used but no text was provided for refs named (see the help page).
↑ Holford NH (December 1986). "Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship". Clinical Pharmacokinetics. 11 (6): 483–504. doi:10.2165/00003088-198611060-00005. PMID 3542339. S2CID 92210077.
↑ Tornkvist, Max; Smith, J. Gustav; Labaf, Ashkan (2018-02-01). "Current evidence of oral anticoagulant reversal: A systematic review". Thrombosis Research. 162: 22–31. doi:10.1016/j.thromres.2017.12.003. ISSN 0049-3848. PMID 29258056.
↑ ^9.0 ^9.1 "Warfarin Monograph for Professionals". Drugs.com. Retrieved 2022-11-14.

[Drugs.com_pregnancy-1] "Warfarin Use During Pregnancy". Drugs.com. 4 September 2019. Archived from the original on 9 February 2018. Retrieved 7 February 2020.

[brands-2] Cite error: The named reference brands was used but no text was provided for refs named (see the help page).

[brands2-3] Cite error: The named reference brands2 was used but no text was provided for refs named (see the help page).

[brands3-4] Cite error: The named reference brands3 was used but no text was provided for refs named (see the help page).

[Coumadin_FDA_label-5] "Coumadin- warfarin sodium tablet". DailyMed. Archived from the original on 26 December 2021. Retrieved 25 December 2021.

[TGA-6] 6.0 ^6.1 ^6.2 ^6.3 Cite error: The named reference TGA was used but no text was provided for refs named (see the help page).

[PCK-7] Holford NH (December 1986). "Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship". Clinical Pharmacokinetics. 11 (6): 483–504. doi:10.2165/00003088-198611060-00005. PMID 3542339. S2CID 92210077.

[8] Tornkvist, Max; Smith, J. Gustav; Labaf, Ashkan (2018-02-01). "Current evidence of oral anticoagulant reversal: A systematic review". Thrombosis Research. 162: 22–31. doi:10.1016/j.thromres.2017.12.003. ISSN 0049-3848. PMID 29258056.

[:0-9] 9.0 ^9.1 "Warfarin Monograph for Professionals". Drugs.com. Retrieved 2022-11-14.

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