Clot

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A clot is a semi-solid substance that blood forms, especially when it is in air. When a person bleeds, the blood turns into a clot at the injury.

When blood makes a clot, it is also called coagulation.

If a person gets a cut on their body, that person may bleed. To stop the bleeding, the human body does several things. First, the brain orders the liver to produce chemicals that will help the clot to form. When the chemicals released by the liver arrive at the injury, the coagulation begins. In the mean time, the brain also lessens the blood flow near the injury (by tightening the veins and arteries in that area), so that not as much blood is lost.

There is a limit to how quickly a clot can form. If the cut is very deep and the person bleeds too much, a clot may not be able to form and a lot of blood may be lost.

The details[change | edit source]

Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. When blood is exposed to proteins such as tissue factor it starts changes to blood platelets and the plasma protein fibrinogen, which is a clotting factor. Platelets immediately form a plug at the site of injury. Proteins in the blood plasma, called coagulation factors or clotting factors, respond in a complex cascade to form fibrin strands. These strengthen the platelet plug.[1]

Coagulation is highly conserved throughout biology; that means its genetics is almost the same in all mammal species. In all mammals, coagulation involves both a cellular (platelet) and a protein (coagulation factor) component.[2] The system in humans has been the most extensively researched and is the best understood.[3]

Blood coagulation pathways in vivo showing the central role played by thrombin

References[change | edit source]

  1. Furie B. & Furie B.C. 2005. "Thrombus formation in vivo". J. Clin. Invest. 115 (12): 3355–62. doi:10.1172/JCI26987. PMC 1297262. PMID 16322780. http://www.jci.org/cgi/content/full/115/12/3355.
  2. Michelson, Alan D. 2006. Platelets. Academic Press. pp. 3–5. ISBN 978-0-12-369367-9. http://books.google.com/books?id=GnIQGmiSylkC&pg=PA3. Retrieved 18 October 2012.
  3. Lillicrap, David et al 2009. Practical hemostasis and thrombosis. Wiley-Blackwell. pp. 1–5. ISBN 1-4051-8460-4.