Methotrexate

Methotrexate
Systematic (IUPAC) name
(2S)-2-[(4-{[(2,4-diamino-7,8-dihydropteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid
Identifiers
CAS number	59-05-2
ATC code	L01BA01 L04AX03
PubChem	126941
DrugBank	APRD00353
ChemSpider	112728
Chemical data
Formula	C20H22N8O5
Mol. mass	454.44 g/mol
Pharmacokinetic data
Bioavailability	17–90%
Metabolism	hepatic
Half life	3–15 hours (dose dependent)
Excretion	renal 48–100%
Therapeutic considerations
Pregnancy cat.	D(AU) X(US)
Legal status	Prescription Only (S4)(AU) POM(UK) ℞-only(US)
Routes	oral, IV, IM, SC, intrathecal

Methotrexate is a drug. It is used to treat cancer and other autoimmune diseases. It can also be used to cause a medical abortion in the early stages of pregnancy.