Quetiapine

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Quetiapine
Systematic (IUPAC) name
2-(2-(4-dibenzo[b,f][1,4]thiazepine- 11-yl- 1-piperazinyl)ethoxy)ethanol
Identifiers
CAS number 111974-69-7
ATC code N05AH04
PubChem 5002
DrugBank DB01224
ChemSpider 4827
Chemical data
Formula C21H25N3O2S 
Mol. mass 383.5099 g/mol
SMILES eMolecules & PubChem
Physical data
Solubility in water 3.29 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability 100%[1]
Protein binding 83%[2]
Metabolism Hepatic via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[3]
Half life 7 hours (parent compound); 9-12 hours (active metabolite, norquetiapine)[2]
Excretion Renal (73%), faeces (20%)[1][2][4]
Therapeutic considerations
Licence data

US FDA:link

Pregnancy cat.

B3(AU) C(US)

Legal status

Prescription Only (S4)(AU) POM(UK) -only(US)

Routes Oral

Quetiapine (better known as Seroquel) is an antipsychotic drug used to treat bipolar disorder and unipolar major depression, though it is used off-label for anxiety problems, Tourette syndrome and autism issues. The side effects of Quetiapine include fatigue, dry mouth and being sleepy. The medication is sometimes used for PTSD.

References[change | change source]

  1. 1.0 1.1 "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. http://reference.medscape.com/drug/seroquel-xr-quetiapine-342984#10. Retrieved 11 October 2013.
  2. 2.0 2.1 2.2 "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. http://www.medicines.org.uk/emc/medicine/26575/SPC/Quetiapine+25+mg+film-coated+tablets/. Retrieved 20 October 2013.
  3. Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman’s The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.
  4. "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC"]. DailyMed. Ascend Laboratories, LLC. October 2013. http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3112a006-1c61-47f2-84f5-9a7670d09c9b. Retrieved 26 November 2013.