User:EpochFail/Cannabis Effects

From Simple English Wikipedia, the free encyclopedia

Effects[change | change source]

Short Term[change | change source]

  • Duration of the high
  • Characteristics of the high
    • Euphoria
    • Hilarity
    • Increased heart rate
    • Paranoia

Long Term[change | change source]

  • Addiction
    • Dependence and withdrawal symptoms are mild [1]
    • High doses are not followed by adverse withdrawal symptoms [2] [3]
  • Amotivational syndrome
    • First speculated about in the 60s [4] [5]
    • In studies of highschool and college students, no detrimental effect was found to grade point averages or probability of graduation [6] [7] [8]
    • Studies suggest that cannabis has no significant impact on learning [9] or motivation [10] unless given unless subjects were required consume unusually high doses and even then, the effects were mild and only lasted one day. [11]
  • Respiratory/Cardiovascular function
    • Smoking has tar, tar causes cancer
    • Vaporizers reduce the adverse effects of smoking. [12] [13] [14]
    • No increased risk of heart disease [15]
  • Cancer
    • Cannabis smoke contains more tar that cigarette smoke [16]
    • Active compounds have anti-cancer effects
      • Cannabis use is negatively correlated with neck and lung cancers [17] [18]
      • THC can be used to treat lung cancer [19]
      • CBD is effective for treating breast cancer [20]
      • THC reduces prostate cancer growth [21]
  • Psychological
    • Correlation between cannabis use and some psychoses [22] [23]
      • Causation is still debated
        • Some studies conclude that cannabis seems to cause psychoses [24]
        • Some studies conclude that psychosis seems to cause cannabis use [25] [26]
        • A statistical analysis of psychotic episodes associated with cannabis use found solid evidence that use did not cause an increased probability of becoming schitzophenic. [27]
        • A 2005 meta analysis of available data which evaluated several hypotheses regarding the correlation of cannabis and psychosis found that there is no support for the hypothesis that cannabis can cause cases of psychosis which would not have occurred otherwise [28]
    • Function MRI shows change in brain function from chronic use [29]
      • No long term behavioral effects have been linked to these changes [30] [31] [32] [33]
    • It is possible that marijuana may have some neuroprotective properties in mitigating alcohol-related oxidative stress or excitotoxic cell death. [34]

Refs[change | change source]

  1. Jones, R.T.; et al. (1976). "Clinical Studies of Cannabis Tolerance and Dependence". Annals of the New York Academy of Sciences. 282: 221–39. {{cite journal}}: Explicit use of et al. in: |author= (help)
  2. Stefanis. C.; et al. (1976). "Experimental Observations of a 3-Day Hashish Abstinence Period and Reintroduction of Use". Annals of the New York Academy of Sciences. 282: 113–20. {{cite journal}}: Explicit use of et al. in: |author= (help)
  3. Cohen, S.; et al. (1976). "The 94-Day Study". The Pharmacology of Marijuana: 621–26. {{cite journal}}: Explicit use of et al. in: |author= (help)
  4. McGlothlin, H.W. and West, L.J. (1968). "The Marijuana Problem: An Overview". American Journal of Psychiatry. 125: 1126–34.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  5. Smith, D.E. (1968). "The Acute and Chronic Toxicity of Marijuana". Journal of Psychedelic Drugs. 2: 37–48.
  6. Brill, N.O. and Christie, R.L. (1974). "Marijuana Use and Psychosocial Adaptation". Archives of General Psychiatry. 31: 713–19.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  7. Kupfer, D.J.; et al. (1973). "A Comment on the Amotivational Syndrome in Marijuana Smokers". American Journal of Psychiatry. 130: 1319–22. {{cite journal}}: Explicit use of et al. in: |author= (help)
  8. Mellinger, G.D.; et al. (1976). "The Amotivational Syndrome and the College Student". Annals of the New York Academy of Sciences. 282: 37–55. {{cite journal}}: Explicit use of et al. in: |author= (help)
  9. Cohen, S. (1976). "The 94-Day Cannabis Study". Annals of the New York Academy of Sciences. 282: 211–20.
  10. Mendelson, J.H.; et al. (1976). "The Effects of Marijuana Use on Human Operant Behavior: Individual Data". The Pharmacology of Marijuana. 2 (M.C. Braude and S. Szara (eds)): 643–53. {{cite journal}}: Explicit use of et al. in: |author= (help)
  11. Campbell, I. "The Amotivational Syndrome and Cannabis use with Emphasis on the Canadian Scene". Annals of the New York Academy of Sciences. 282: 33–36.
  12. Franjo Grotenhermen (2001). "Harm Reduction Associated with Inhalation and Oral Administration of Cannabis and THC". Journal of Cannabis Therapeutics. 1 (3–4): 133–152. doi:10.1300/J175v01n03_09. {{cite journal}}: Unknown parameter |month= ignored (help)
  13. Earleywine M, Barnwell SS (2007). "Decreased Respiratory Symptoms in Cannabis Users Who Vaporize". Harm Reduction Journal. 4: 11. doi:10.1186/1477-7517-4-11. PMC 1853086. PMID 17437626.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  14. Hazekamp A, Ruhaak R, Zuurman L, van Gerven J, Verpoorte R (2006). "Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol". Journal of Pharmaceutical Sciences. 95 (6): 1308–1317. doi:10.1002/jps.20574. PMID 16637053. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  15. Mukamal KJ, Maclure M, Muller JE, Mittleman MA (2008). "An exploratory prospective study of marijuana use and mortality following acute myocardial infarction". American Heart Journal. 155 (3): 465–70. doi:10.1016/j.ahj.2007.10.049. PMC 2276621. PMID 18294478. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  16. S. Aldington, M. Harwood, B. Cox, M. Weatherall, L. Beckert, A. Hansell, A. Pritchard, G. Robinson, R. Beasley (2008). "Cannabis use and risk of lung cancer: a case–control study". European Respiratory Journal. 31: 280–86. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  17. Liang C, McClean MD, Marsit C, Christensen B, Peters E, Nelson HH, Kelsey KT. (2009). "A population-based case-control study of marijuana use and head and neck squamous cell carcinoma". Cancer Prevention Research. 8: 759–68. PMID 19638490. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  18. "Study Finds No Link Between Marijuana Use And Lung Cancer". Science Daily. 2006-05-26.
  19. "Δ-9 Tetrahydrocannabinol inhibits growth and metastasis of lung cancer: Abstract 4749" (Press release). American Association for Cancer Research. 2007-04-17.
  20. McAllister, S.D. , Christian, R.T., Horowitz, M.P., Garcia, A. and Desprez. P (2007). "Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells". Molecular Cancer Therapeutics. 6: 2921-2927. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  21. Ben Hirschler. "Cannabis chemicals may help fight prostate cancer". Reuters. Retrieved 19 August 2009.
  22. Henquet C, Krabbendam L, Spauwen J; et al. (2005). "Prospective Cohort Study of Cannabis Use, Predisposition for Psychosis, and Psychotic Symptoms in Young People". British Medical Journal. 330 (7481): 11. doi:10.1136/bmj.38267.664086.63. PMC 539839. PMID 15574485. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  23. Patton GC, Coffey C, Carlin JB, Degenhardt L, Lynskey M, Hall W (2002). "Cannabis Use and Mental Health in Young People: Cohort Study". British Medical Journal. 325 (7374): 1195–1198. doi:10.1136/bmj.325.7374.1195. PMC 135489. PMID 12446533. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  24. Fergusson DM, Horwood LJ, Ridder EM (2005). "Tests of Causal Linkages Between Cannabis Use and Psychotic Symptoms". Addiction. 100 (3): 354–366. doi:10.1111/j.1360-0443.2005.01001.x. PMID 15733249. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  25. Hall, Wayne; Degenhardt, Lousia; Teesson, Maree (2004). "Cannabis Use and Psychotic Disorders: An Update". Drug and Alcohol Review. 23 (4): 433–443. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  26. Arseneault, Louise; Cannon, Mary; Wiitton, John; Murray, Robin M (2004). "Causal Association Between Cannabis and Psychosis: Examination of the Evidence" (PDF). British Journal of Psychiatry. 184: 110–117.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  27. Mikkel Arendt; Preben B. Mortensen; Raben Rosenberg; Carsten B. Pedersen; Berit L. Waltoft (2008). "Familial Predisposition for Psychiatric Disorder: Comparison of Subjects Treated for Cannabis-Induced Psychosis and Schizophrenia". Archives of General Psychiatry. 65 (11): 1269–1274.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  28. Degenhardt L, Hall W, Lynskey M (2001). "Comorbidity between cannabis use and psychosis: Modelling some possible relationships. Technical Report No. 121" (PDF). Sydney: National Drug and Alcohol Research Centre. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: multiple names: authors list (link)
  29. Gonzalez R (2007). "Acute and Non-Acute Effects of Cannabis on Brain Functioning and Neuropsychological Performance". Neuropsychology Review. 17 (3): 347–61. doi:10.1007/s11065-007-9036-8. PMID 17680367. {{cite journal}}: Unknown parameter |month= ignored (help)
  30. Satz, P.; et al. (1976). "Neuropsychologic, Intellectual, and Personality Correlates of Chronic Marijuana Use in Native Costa Ricans". Annals of the New York Academy of Sciences. 282: 266–306. {{cite journal}}: Explicit use of et al. in: |author= (help)
  31. Grant, I.; et al. (1973). "A Neuropsychological Assessment of the Effects of Moderate Marijuana Use". Journal of Nervous and Mental Disease. 156: 278–80. {{cite journal}}: Explicit use of et al. in: |author= (help)
  32. Page, J.B. (1988). "Psychosociocultural Perspectives on Chronic Cannabis Use: The Costa Rican Follow-Up". Journal of Psychoactive Drugs. 20: 57–65.
  33. Carlin, A.S. and Trupin, E.W. (1977). "The Effect of Long-Term Chronic Marijuana Use on Neuropsychological Functioning". International Journal of the Addictions. 12: 617–24.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  34. J. Jacobusa, T. McQueenyg, S. Bavab, B.C. Schweinsburge, L.R. Frankb, T.T. Yangc and S.F. Taper (2009). "White matter integrity in adolescents with histories of marijuana use and binge drinking". Neurotoxicology and Teratology. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)