Catalepsy

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Catalepsy
Classification and external resources
ICD-10F20.2, F44.2
ICD-9295.2, 300.11
MeSHD002375
Rgigidity of the body is characteristic of catalepsy

Catalepsy is a nervous condition. The body is fixed, with rigid muscles and fixed posture. The body position does not respond to stimuli, and there is decreased sensitivity to pain.[1]

Causes[change | change source]

Catalepsy is a symptom of certain nervous disorders or conditions such as Parkinson's disease and epilepsy. It is also a characteristic symptom of cocaine withdrawal. It may be caused by schizophrenia treatment with anti-psychotics such as haloperidol.[2][3] It may be caused by the anaesthetic ketamine.[4] In some cases, catalepsy may be started by an extreme emotional shock – one well known example of this was the reaction of 1968 Olympic long jump medalist Bob Beamon on finding he had broken the previous world record by over 0.5 meters (2 feet).[5] Protein kinase A has been suggested as a mediator of cataleptic behavior.[6]

References[change | change source]

  1. Medical terms
  2. Rasmussen K. et al (2007). "The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptoms". Schizophr Bull 33 (6): 1291–7. doi:10.1093/schbul/sbm087. PMC 2779883. PMID 17660489. http://schizophreniabulletin.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17660489. 
  3. Hattori K. et al. (2006). "Fyn is required for haloperidol-induced catalepsy in mice". J. Biol. Chem. 281 (11): 7129–35. doi:10.1074/jbc.M511608200. PMID 16407246. http://www.jbc.org/cgi/pmidlookup?view=long&pmid=16407246. 
  4. Miller, Ronald (2005). Miller's Anesthesia. New York: Elsevier/Churchill Livingstone. ISBN 0-443-06656-6.
  5. Great Olympic Moments - Sir Steve Redgrave, 2011
  6. Adams M.R. et al (1997). "Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice". Proc. Natl. Acad. Sci. U.S.A. 94 (22): 12157–61. doi:10.1073/pnas.94.22.12157. PMC 23735. PMID 9342379. http://www.pnas.org/cgi/pmidlookup?view=long&pmid=9342379.