Klinefelter syndrome

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Klinefelter syndrome, 47, XXY, or XXY syndrome is a genetic disorder where people have an extra number of X chromosomes.[1] People who have Klinefelter's Syndrome are often called "XXY Males", or "47, XXY Males".[2][dead link]

Effects[change | change source]

Males who have this condition are almost always infertile. This means that they cannot father babies.[3]

In other organisms[change | change source]

Other males can have Klinefelter's Syndrome as well as humans. The mouse is one example.[4] Tortoiseshell or calico markings on male cats are an indicator of a similar syndrome. These cats are considered to be the model organism for Klinefelter syndrome, because the gene for a cat's tabby coat markings is found on the X chromosome. [5]

References[change | change source]

  1. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 179. ISBN 0-7216-0187-1.CS1 maint: Multiple names: authors list (link)
  2. Bock, Robert (1993). "Understanding Klinefelter Syndrome: A Guide for XXY Males and their Families" (HTML). NIH Pub. No. 93-3202. Office of Research Reporting, NICHD. Retrieved 2007-04-07.
  3. Denschlag, Dominik, MD; Clemens, Tempfer, MD; Kunze, Myriam, MD; Wolff, Gerhard, MD; Keck, Christoph, MD (October 2004). "Assisted reproductive techniques in patients with Klinefelter syndrome: A critical review". Fertility and Sterility 82 (4): 775–779. doi:10.1016/j.fertnstert.2003.09.085. PMID 15482743 
  4. Russell, Liane Brauch (9 June 1961). "Genetics of Mammalian Sex Chromosomes MOUSE STUDIES THROW LIGHT ON THE FUNCTIONS AND ON THE OCCASIONALLY ABERRANT BEHAVIOR OF SEX CHROMOSOMES". Science 133 (3467): 1795-1803. doi:10.1126/science.133.3467.1795 
  5. Centerwall WR, Benirschke K (1975). "An animal model for the XXY Klinefelter's syndrome in man: Tortoiseshell and calico male cats". American Journal of Veterinary Research 36 (9): 1275–1280. PMID 1163864. 

Other websites[change | change source]