M6 or M-6 may mean:
- M6 motorway, a motorway in the United Kingdom
- M6 Toll, a toll motorway in the United Kingdom that relieves traffic on the M6 motorway
- M6 (Ireland), a motorway-grade section of the N6 road in the Republic of Ireland
- M6 motorway (Hungary), a motorway in Hungary
- M-6 (Michigan highway), a state highway in southern Michigan
- Russian route M6 is another name for the Caspian Highway in Russia
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