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Nephritis is inflammation of the kidneys. It may involve the glomeruli, tubules, or interstitial tissue surrounding the glomeruli and tubules.[1]

Nephritis is often caused by infections, and toxins, but is most commonly caused by autoimmune disorders that affect the major organs like kidneys.[2]

Nephritis can produce glomerular injury, by disturbing the glomerular structure with inflammatory cell proliferation.[3] This can lead to reduced glomerular blood flow, leading to reduced urine output (oliguria)[4] and retention of waste products (uremia).[5] As a result, red blood cells may leak out of damaged glomeruli, causing blood to appear in the urine (hematuria).[6]

References[change | change source]

  1. Keto Acids – Advances in Research and Application 2013 Edition p.220e
  2. "Acute Nephritis; Nephrosis; Nephritic syndrome information. Patient | Patient". Patient. Retrieved 23 July 2016.
  3. "Glomerular Diseases". Archived from the original on 2015-06-12. Retrieved 2015-06-15.
  4. "Oliguria: Background, Etiology, Epidemiology". Medscape. eMedicine. Retrieved 23 July 2016.
  5. "uremia | accumulation in the blood of constituents normally eliminated in the urine that produces a severe toxic condition and usually occurs in severe kidney disease". Retrieved 2015-06-14.
  6. "Hematuria (Blood in the Urine)". Archived from the original on 2016-06-24. Retrieved 2015-06-14.