In a point mutation, either:
- a single base nucleotide is changed for another nucleotide of the genetic material (normally DNA), or
- a single base pair is inserted or deleted.
A nonsense mutation is a point mutation in a DNA sequence that leads to an early stop codon. This appears as a nonsense codon in the transcribed mRNA. Most of the time, the protein that is translated from this mRNA does not work.
References[change | change source]
- "What is a mutation?". University of Texas, El Passo. http://utminers.utep.edu/rwebb/html/what_is_a_mutation_.html. Retrieved January 23, 2017.
- "Glossary: point mutation". Rosalind. http://rosalind.info/glossary/point-mutation/. Retrieved January 23, 2017.
- "How DNA changes affect phenotype". National Center for Biotechnology Information, U.S. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK21955/. Retrieved January 23, 2017.
- Eldon D Enger; Frederick C Ross; David B Bailey, Concepts in Biology, 12th Edition (London: McGraw-Hill, 2007), p. 158