Point mutation

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Illustration of three types of point mutations.

A point mutation is a single base substitution.[1] It is the smallest type of mutation possible.

In a point mutation, either:

  1. a single base nucleotide is changed for another nucleotide of the genetic material (normally DNA),[2] or
  2. a single base pair is inserted or deleted.[3]

A nonsense mutation is a point mutation in a DNA sequence that leads to an early stop codon.[4] This appears as a nonsense codon in the transcribed mRNA. Most of the time, the protein that is translated from this mRNA does not work.

References[change | change source]

  1. "What is a mutation?". University of Texas, El Passo. http://utminers.utep.edu/rwebb/html/what_is_a_mutation_.html. Retrieved January 23, 2017.
  2. "Glossary: point mutation". Rosalind. http://rosalind.info/glossary/point-mutation/. Retrieved January 23, 2017.
  3. "How DNA changes affect phenotype". National Center for Biotechnology Information, U.S. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK21955/. Retrieved January 23, 2017.
  4. Eldon D Enger; Frederick C Ross; David B Bailey, Concepts in Biology, 12th Edition (London: McGraw-Hill, 2007), p. 158