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ProSci Incorporated

From Simple English Wikipedia, the free encyclopedia
Company typePrivate
  • Research Use Antibodies
  • Recombinant Proteins
  • Research Tools
  • Custom Antibody Services – Polyclonal, Monoclonal, Recombinant, Single Domain (VHH)

ProSci is an American biotechnology company with offices located in Poway, California.

The Poway site focuses on manufacturing antibodies[1] for use in research studies leading to diagnostics and therapy development. They specialize in producing a range of antibodies using polyclonal, monoclonal, and recombinant production techniques. ProSci has been a pioneer in the development of commercially available single domain antibodies (VHH – variable heavy chain) derived from camelid species, including llamas and alpacas.[2]

History[change | change source]

ProSci Incorporated was co-founded in 1998 by Yu Geng, M.D.[3][4] with the mission to develop neutralizing antibodies against emergent viruses. Their innovative approach using genetically engineered yeast strains and glycoproteins to mimic the HIV-1 glycan coat led to the development of neutralizing antibodies against HIV-1 glycans.

Early in 2020, ProSci was one of only a handful of companies that had antibodies available that recognized key proteins of the SARS-CoV-2 virus. Their reagents led to key discoveries on the mechanism of entry as well as neutralization of the SARS-CoV-2 virus.  

Today, ProSci continues to offer tens of thousands of antibodies and custom antibody services to help researchers advance discoveries in the life sciences.  

References[change | change source]

  1. "Sapphire Bioscience". www.sapphirebioscience.com. Retrieved 2023-06-09.
  2. Jiang, Yixiang; Lin, Yan; Krishnaswamy, Senthilkumar; Pan, Ruimin; Wu, Qian; Sandusky-Beltran, Leslie A.; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Congdon, Erin E.; Sigurdsson, Einar M. (2023-05-10). "Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology". Science Advances. 9 (19). doi:10.1126/sciadv.adf3775. ISSN 2375-2548. PMC 10171817. PMID 37163602.
  3. "HIGH PERFORMANCE ANTIBODIES ... AND MORE". Nature (journal). Retrieved 26 April 2016.
  4. "Yu Geng ProSci Incorporated". ZoomInfo. Archived from the original on 2 June 2016. Retrieved 26 April 2016.

Other websites[change | change source]