ProSci Incorporated

From Simple English Wikipedia, the free encyclopedia
Jump to navigation Jump to search
ProSci Incorporated
Private
Founded1998
FounderYu Geng
Headquarters,
Services
  • Research antibody products
  • Custom antibody services
  • Research and development of neutralizing antibodyagainst HIV-1 and other emergent viruses
Websitewww.prosci-inc.com

ProSci Incorporated is an American biotechnology company located in San Diego, California[1] that specializes in research antibody[2] products and custom antibody services and conducts research and development of neutralizing antibodyagainst HIV-1[3] and other emergent viruses.[4]

History[change | change source]

ProSci Incorporated was co-founded in 1998 by CEO, Yu Geng, M.D.[5][6] ProSci has its own animal facilities since 2010 solely in San Diego. The animal facility is United State Department of Agriculture (USDA) licensed and National Institute of Health (NIH) assured and close to the company headquarter, which ensures the capability and quality of antibody development, custom antibody services and research applications.[7]

Research[change | change source]

ProSci research programs include cancer bio marker discovery and neutralizing antibody development against emergent viruses such as HIV[8] and influenza. ProSci’s innovative approach research using genetically engineered yeast strain and glycoproteins to mimic the HIV-1 glycan coat and develop neutralizing antibodies against HIV-1 glycans has been awarded several Small Business Innovative Research (SBIR) grants by NIH.[9] Its research projects have resulted in an invention patent granted by the U.S. Patent and Trademark Office,[10] and a number of peer-reviewed publications.[11][12]

Products and Services[change | change source]

ProSci specializes in the production of affinity-purified polyclonal and monoclonal antibodies to novel targets in the fields such as apoptosis, HIV, infectious disease, immunology, immune checkpoint, signal transduction, cancer and neurobiology.[13][14] To date, ProSci has a primary antibody catalog of over 20,000 antibodies. Other catalog items include blocking peptides, recombinant proteins, tissue and cell line slides and lysates.[15]

References[change | change source]

  1. "ProSci Incorporated: Private Company Information - Businessweek". Bloomberg L.P. Retrieved 26 April 2016.
  2. "Single Domain Antibody Production : Custom Antibodies by ProSci Incorporated". Sapphire Bioscience. Retrieved 26 April 2016.
  3. "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". National Institutes of Health. Retrieved 26 April 2016.
  4. "ProSci released 3rd antibody". The San Diego Union-Tribune. Archived from the original on 3 June 2016. Retrieved 26 April 2016.
  5. "HIGH PERFORMANCE ANTIBODIES ... AND MORE". Nature (journal). Retrieved 26 April 2016.
  6. "Yu Geng ProSci Incorporated". ZoomInfo. Archived from the original on 2 June 2016. Retrieved 26 April 2016.
  7. Luallen, R. J.; Fu, H.; Agrawal-Gamse, C.; Mboudjeka, I.; Huang, W.; Lee, F. H.; Wang, L. X.; Doms, R. W.; Geng, Y. (22 September 2015). "A Yeast Glycoprotein Shows High-Affinity Binding to the Broadly Neutralizing Human Immunodeficiency Virus Antibody". Journal of Virology. National Institutes of Health. 83 (10): 5140–5147. doi:10.1128/JVI.02537-08. PMC 2682088. PMID 19264785.
  8. Geng, Yu. "Developing Broadly Neutralizing MAbs for an HIV Vaccine". Grantome : National Institute of Health. Retrieved 26 April 2016.
  9. "Project Information - NIH RePORTER - NIH Research Portfolio Online Reporting Tools Expenditures and Results". National Institutes of Health. Retrieved 26 April 2016.
  10. "US Patent Application for Glycosylated polypeptides produced in yeast mutants and methods of use thereof Patent Application (Application #20080038286 issued February 14, 2008) - Justia Patents Search". Patents Justia (US Gov). Retrieved 26 April 2016.
  11. Luallen, Robert J.; Fu, Hu; Agrawal-Gamse, Caroline; Mboudjeka, Innocent; Huang, Wei; Lee, Fang-Hua; Wang, Lai-Xi; Doms, Robert W.; Geng, Yu (15 May 2009). "A Yeast Glycoprotein Shows High-Affinity Binding to the Broadly Neutralizing Human Immunodeficiency Virus Antibody 2G12 and Inhibits gp120 Interactions with 2G12 and DC-SIGN". Journal of Virology. 83 (10): 4861–4870. doi:10.1128/JVI.02537-08. ISSN 0022-538X. PMC 2682088. PMID 19264785. Retrieved 26 April 2016.[permanent dead link]
  12. Luallen, R. J.; Agrawal-Gamse, C.; Fu, H.; Smith, D. F.; Doms, R. W.; Geng, Y. (1 March 2010). "Antibodies against Manα1,2-Manα1,2-Man oligosaccharide structures recognize envelope glycoproteins from HIV-1 and SIV strains". Glycobiology (journal). 20 (3): 280–286. doi:10.1093/glycob/cwp184. ISSN 0959-6658. PMC 2815653. PMID 19920089. Retrieved 26 April 2016.
  13. Sabirzhanov, B.; Stoica, B. A.; Zhao, Z.; Loane, D. J.; Wu, J.; Dorsey, S. G.; Faden, A. I. (2016). "miR-711 upregulation induces neuronal cell death after traumatic brain injury". Nature (journal). 23 (4): 654–668. doi:10.1038/cdd.2015.132. PMC 4986637. PMID 26470728.
  14. Anti-Human CCR5 Polyclonal (NT) (PDF) (Catalog Number: 11232 ed.). USA: Aids re-agent. p. 35. Retrieved 26 April 2016.[permanent dead link]
  15. "ProSci Antibody Catalog" (PDF). Caltag Laboratories - UK. Retrieved 26 April 2016.

Other websites[change | change source]