|Classification and external resources|
A young girl with progeria (left). A healthy cell nucleus (right, top) and a progeric cell nucleus (right, bottom).
|ICD-10||E34.8 (ILDS E34.840)|
Progeria ( //), also called Hutchinson–Gilford progeria syndrome and HGPS progeria syndrome is a very rare genetic disorder. Children born with progeria show symptoms which are like aging. This can include skin wrinkles and grey hair or baldness. Progeria is one of several progeroid syndromes. The word progeria comes from the Greek words "pro" (πρό), meaning "before" or "premature", and "gēras" (γῆρας), meaning "old age".
It is very rare, only 1 child in every 8 million live births. People with progeria usually only live to their mid teens to early twenties. It is a genetic condition that occurs as a new mutation. It is rarely inherited, as people with the condition do not usually live long enough to have children.
Scientists are studying progeria because it might reveal clues about the normal process of aging. Progeria was first described in 1886 by Jonathan Hutchinson. It was also described independently in 1897 by Hastings Gilford. The condition was later named Hutchinson–Gilford progeria syndrome.
References[change | change source]
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- McClintock D, Ratner D, Lokuge M; Lokuge; Owens; Gordon; Collins; Djabali; et al. (2007). Lewin, Alfred (ed.). "The Mutant Form of Lamin A that Causes Hutchinson-Gilford Progeria Is a Biomarker of Cellular Aging in Human Skin". PLoS ONE. 2 (12): e1269. Bibcode:2007PLoSO...2.1269M. doi:10.1371/journal.pone.0001269. PMC 2092390. PMID 18060063. Missing
|author2=(help)CS1 maint: multiple names: authors list (link)
- Korf B (2008). "Hutchinson-Gilford progeria syndrome, aging, and the nuclear lamina". N. Engl. J. Med. 358 (6): 552–5. doi:10.1056/NEJMp0800071. PMID 18256390.
- Merideth MA, Gordon LB, Clauss S; et al. (2008). "Phenotype and course of Hutchinson-Gilford progeria syndrome". N. Engl. J. Med. 358 (6): 592–604. doi:10.1056/NEJMoa0706898. PMC 2940940. PMID 18256394.CS1 maint: multiple names: authors list (link)
- Hutchinson J (1886). "Case of congenital absence of hair, with atrophic condition of the skin and its appendages, in a boy whose mother had been almost wholly bald from alopecia areata from the age of six". Lancet. I (3272): 923. doi:10.1016/S0140-6736(02)06582-0.
- Gilford H; Shepherd, RC (1904). "Ateleiosis and progeria: continuous youth and premature old age". Brit. Med. J. 2 (5157): 914–8. PMC 1990667. PMID 14409225.