Roanoke may refer to:
- The Roanoke people, who once lived in North Carolina.
- Roanoke Colony, a failed British colony.
- Roanoke Island, where Roanoke Colony was created.
- Roanoke, Alabama
- Roanoke, Texas
- Roanoke, Virginia
- Roanoke Rapids, North Carolina
| This disambiguation page lists articles associated with the title Roanoke.
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