At the start, Saccharin was marketed in boxes such as this one. The text says: "Sweetener Saccharin, 1000 boxes of 1000 tablets each."
Saccharin is the oldest artificial sweetener that exists. It can be used to replace certain kinds of sugar. It was discovered in 1878 by Constantin Fahlberg. It is also known as E954.
Warning notice on a can of an artificially sweetened drink: Saccharin has been shown to cause cancer in laboratory animals