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User:Mr. Ibrahem/Chronic kidney disease

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Chronic kidney disease
Other namesChronic renal disease, kidney failure, impaired kidney function[1]
Uremic frost on the head in someone with chronic kidney disease
Medical specialtyNephrology
SymptomsEarly: None[2]
Later: Leg swelling, feeling tired, vomiting, loss of appetite, confusion[2]
ComplicationsHeart disease, high blood pressure, anemia[3][4]
DurationLong-term[5]
CausesDiabetes, high blood pressure, glomerulonephritis, polycystic kidney disease[5][6]
Diagnostic methodBlood tests, urine tests[7]
TreatmentMedications to manage blood pressure, blood sugar, and lower cholesterol, renal replacement therapy, kidney transplant[8][9]
Frequency753 million (2016)[1]
Deaths1.2 million (2015)[6]

Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years.[2][5] Initially there are generally no symptoms; later, symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion.[2] Complications include an increased risk of heart disease, high blood pressure, bone disease, and anemia.[3][4][10]

Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease.[5][6] Risk factors include a family history of chronic kidney disease.[2] Diagnosis is by blood tests to measure the estimated glomerular filtration rate (eGFR), and a urine test to measure albumin.[7] Ultrasound or kidney biopsy may be performed to determine the underlying cause.[5] Several severity-based staging systems are in use.[11][12]

Screening at-risk people is recommended.[7] Initial treatments may include medications to lower blood pressure, blood sugar, and cholesterol.[9] Angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor antagonists (ARBs) are generally first-line agents for blood pressure control, as they slow progression of the kidney disease and the risk of heart disease.[13] Loop diuretics may be used to control edema and, if needed, to further lower blood pressure.[14][9][15] NSAIDs should be avoided.[9] Other recommended measures include staying active, and certain dietary changes such as a low-salt diet and the right amount of protein.[9][16] Treatments for anemia and bone disease may also be required.[17][18] Severe disease requires hemodialysis, peritoneal dialysis, or a kidney transplant for survival.[8]

Chronic kidney disease affected 753 million people globally in 2016: 417 million females and 336 million males.[1] In 2015 it caused 1.2 million deaths, up from 409,000 in 1990.[6][19] The causes that contribute to the greatest number of deaths are high blood pressure at 550,000, followed by diabetes at 418,000, and glomerulonephritis at 238,000.[6]

References

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  1. ↑ 1.0 1.1 1.2 Bikbov B, Perico N, Remuzzi G (23 May 2018). "Disparities in Chronic Kidney Disease Prevalence among Males and Females in 195 Countries: Analysis of the Global Burden of Disease 2016 Study". Nephron. 139 (4): 313–318. doi:10.1159/000489897. PMID 29791905. Archived (PDF) from the original on 28 August 2021. Retrieved 27 May 2020.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "What Is Chronic Kidney Disease?". National Institute of Diabetes and Digestive and Kidney Diseases. June 2017. Archived from the original on 21 December 2017. Retrieved 19 December 2017.
  3. ↑ 3.0 3.1 Liao MT, Sung CC, Hung KC, Wu CC, Lo L, Lu KC (2012). "Insulin resistance in patients with chronic kidney disease". Journal of Biomedicine & Biotechnology. 2012: 691369. doi:10.1155/2012/691369. PMC 3420350. PMID 22919275.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  4. ↑ 4.0 4.1 "Kidney Failure". MedlinePlus. Archived from the original on 4 July 2016. Retrieved 11 November 2017.
  5. ↑ 5.0 5.1 5.2 5.3 5.4 "What is renal failure?". Johns Hopkins Medicine. Archived from the original on 18 June 2017. Retrieved 18 December 2017.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 GBD 2015 Mortality Causes of Death Collaborators (October 2016). "Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015". Lancet. 388 (10053): 1459–1544. doi:10.1016/s0140-6736(16)31012-1. PMC 5388903. PMID 27733281. {{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link)
  7. ↑ 7.0 7.1 7.2 "Chronic Kidney Disease Tests & Diagnosis". National Institute of Diabetes and Digestive and Kidney Diseases. October 2016. Archived from the original on 22 December 2017. Retrieved 19 December 2017.
  8. ↑ 8.0 8.1 "Kidney Failure". National Institute of Diabetes and Digestive and Kidney Diseases. Archived from the original on 27 July 2018. Retrieved 11 November 2017.
  9. ↑ 9.0 9.1 9.2 9.3 9.4 "Managing Chronic Kidney Disease". National Institute of Diabetes and Digestive and Kidney Diseases. October 2016. Archived from the original on 2017-12-21. Retrieved 2017-12-19.
  10. ↑ KDIGO: Kidney Disease Improving Global Outcomes (August 2009). "KDIGO Clinical Practice Guideline for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)" (PDF). Kidney Int. 76 (Suppl 113). Archived from the original (PDF) on 2016-12-13.
  11. ↑ "Summary of Recommendation Statements". Kidney International Supplements. 3 (1): 5–14. January 2013. doi:10.1038/kisup.2012.77. PMC 4284512. PMID 25598998.
  12. ↑ Ferri, Fred F. (2017). Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1. Elsevier Health Sciences. pp. 294–295. ISBN 9780323529570. Archived from the original on 2021-08-28. Retrieved 2020-05-27.
  13. ↑ Xie X, Liu Y, Perkovic V, Li X, Ninomiya T, Hou W, et al. (May 2016). "Renin-Angiotensin System Inhibitors and Kidney and Cardiovascular Outcomes in Patients With CKD: A Bayesian Network Meta-analysis of Randomized Clinical Trials". American Journal of Kidney Diseases (Systematic Review & Meta-Analysis). 67 (5): 728–41. doi:10.1053/j.ajkd.2015.10.011. PMID 26597926.
  14. ↑ Wile D (September 2012). "Diuretics: a review". Annals of Clinical Biochemistry. 49 (Pt 5): 419–31. doi:10.1258/acb.2011.011281. PMID 22783025.
  15. ↑ James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. (February 2014). "2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)". JAMA. 311 (5): 507–20. doi:10.1002/14651858.CD011339.pub2. PMC 6485696. PMID 24352797.
  16. ↑ "Eating Right for Chronic Kidney Disease | NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. Archived from the original on 2 October 2019. Retrieved 5 September 2019.
  17. ↑ "Anemia in Chronic Kidney Disease". National Institute of Diabetes and Digestive and Kidney Diseases. July 2016. Archived from the original on 21 December 2017. Retrieved 19 December 2017.
  18. ↑ "Mineral & Bone Disorder in Chronic Kidney Disease". National Institute of Diabetes and Digestive and Kidney Diseases. November 2015. Archived from the original on 22 December 2017. Retrieved 19 December 2017.
  19. ↑ GBD 2013 Mortality Causes of Death Collaborators (January 2015). "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013". Lancet. 385 (9963): 117–71. doi:10.1016/S0140-6736(14)61682-2. PMC 4340604. PMID 25530442. {{cite journal}}: |author1= has generic name (help)CS1 maint: numeric names: authors list (link) Table 2, p. 137 open access publication – free to read
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