Hemoglobin Lepore syndrome

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When two genes, the delta and beta globin gene loci become crossed or mixed-up a mutation happens which causes the Hb Lepore trait.

Hemoglobin Lepore syndrome (Hb Lepore) is a kind of blood disorder that is caused by a genetic mutation. It was first found in an Italian-American family named Lepore. When a genetic mutation runs in families it is known as a trait.

The Hb Lepore trait is found worldwide and may affect people of various races, however the three main kinds of Hb Lepore, usually affects Caucasians of the Southern regions of Central and Eastern Europe.[1]

There are three main kinds of Hb Lepore are named for the areas they were first found in, with various subtypes, the three main kinds are:

References[change | change source]

  1. Loren F. Hazelwood: Can't Live Without It: The Story of Hemoglobin in Sickness and in Health. pp.113-115
  2. McKeown SM, Carmichael H, Markowitz RB, Kutlar A, Holley L, Kutlar F (2009 Jun). "Rare occurrence of Hb Lepore-Baltimore in African Americans: molecular characteristics and variations of Hb Lepores". Ann Hematol 88 (6): 545–8. doi:10.1007/s00277-008-0631-4. PMID 18989669.
  3. Ropero P, Murga MJ, González FA, Polo M, Benavente C, Salvador M, Villegas A (2005). "The first case of Hb E-Saskatoon associated with Hb Lepore-Baltimore found in Spain". Hemoglobin 29 (3): 215–9. PMID 16114185.