Pituitary adenoma

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Pituitary adenoma
Classification and external resources
ICD-10 D35.2
ICD-9 237.0
ICD-O: M8272/0
MedlinePlus 000704
eMedicine neuro/312
MeSH D010911

Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary tumors are generally divided into three kinds dependant upon their biological functioning: benign adenoma, invasive adenoma or carcinomas, with carcinomas accounting for 0.1% to 0.2%, appoximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all brain tumors and is thought to happen in about 17% to 25% of most people.

Non-invasive and non-secreting pituitary adenomas are considered to be benign [harmless]; but a recent large study (Fernández-Balsells, et al. 2011) has shown there are few studies to prove if this is true or not.

Adenomas that are bigger than 10 millimetres (0.39 in) are called macroadenomas, and those smaller than 10 mm are called microadenomas. Most pituitary adenomas are microadenomas.[1][2] Most pituitary microadenomas often remain undiagnosed and those that are diagnosed are often found as an incidental finding [which means found by chance], and are called incidentalomas.

Invasive adenomas may invade the dura mater, cranial bone, or sphenoid bone. It used to be thought that clinically active pituitary adenomas were rare but recent studies have suggested that they may affect about one in 1000 of the general population.[3]

References[change | change source]

  1. Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, McCutcheon IE. (August 2004). "The prevalence of pituitary adenomas: a systematic review". Cancer 101 (3): 613–9. doi:10.1002/cncr.20412. PMID 15274075.
  2. Asa SL (August 2008). "Practical pituitary pathology: what does the pathologist need to know?". Arch. Pathol. Lab. Med. 132 (8): 1231–40. doi:10.1043/1543-2165(2008)132[1231:PPPWDT]2.0.CO;2. PMID 18684022. http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0003-9985&volume=132&page=1231. Retrieved 2008-09-03.
  3. Daly AF, Rixhon M, Adam C et al. High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium. J Clin Endocrinol Metab. 2006 Dec;91(12):4769-75. Epub 2006 Sep 12. PMID 16968795