Exosome complex

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"Ribbon view" of the human exosome complex. PDB 2NN6. The channel through which RNA passes during degradation is visible at the center of the protein complex

The exosome complex is a protein complex which can degrade RNA strands (~stop them working). In eukaryotic cells, the exosome complex is present in the cytoplasm, nucleus, and especially the nucleolus.

The core of the complex has a ring structure consisting of six proteins that all belong to the same class of RNases, the 'RNase PH-like proteins'.[1]

Exosome complexes are found in both eukaryotic cells and archaea. In bacteria a simpler complex called the degradosome carries out similar functions.

References[change | change source]

  1. Schilders G.; et al. (2006). Cell and molecular biology of the exosome: how to make or break an RNA. International Review of Cytology. Vol. 251. pp. 159–208. doi:10.1016/S0074-7696(06)51005-8. ISBN 9780123646552. PMID 16939780.