A haplotype is a term in genetics. It is short for haploid genotype. A haplotype is a collection of specific alleles (particular DNA sequences) in a cluster of tightly-linked genes on a chromosome. A cluster is usually inherited together. Put simply, haplotype is a closely-knit group of genes which a child inherits from one parent.
A second meaning of the term haplotype is a set of single-nucleotide polymorphisms (SNPs) usually found together on a single chromatid (of a chromosome pair). So, finding a few alleles of a haplotype sequence identifies all other sites in its region. Such information is very valuable for investigating the genetics of common diseases.
Comparing haplotypes of two or more people shows the degree of genetic relationship between their respective lines. It is done in genetic genealogy projects.
References[change | change source]
- Kimball's Biology Pages Archived 2015-02-13 at the Wayback Machine (Creative Commons Attribution 3.0)
- SciTable: haplotype / haplotypes 
- The International HapMap Consortium (2003). "The International HapMap Project" (PDF). Nature. 426 (6968): 789–796. Bibcode:2003Natur.426..789G. doi:10.1038/nature02168. hdl:2027.42/62838. PMID 14685227. S2CID 4387110.
- The International HapMap Consortium (2005). "A haplotype map of the human genome" (PDF). Nature. 437 (7063): 1299–1320. Bibcode:2005Natur.437.1299T. doi:10.1038/nature04226. PMC 1880871. PMID 16255080.
- Haplotype versus haplogroup — the difference between haplogroup & haplotype explained.