Genetics is a discipline of biology. It is the science of heredity. This includes the study of genes, and the inheritance of variation and traits of living organisms. In the laboratory, genetics proceeds by mating carefully selected organisms, and analysing their offspring. More informally, genetics is the study of how parents pass some of their characteristics to their children. It is an important part of biology, and gives the basic rules on which evolution acts.
The fact that living things inherit traits from their parents has been known since prehistoric times, and used to improve crop plants and animals through selective breeding. However, the modern science of genetics seeks to understand the process of inheritance. This began with the work of Gregor Mendel in the mid-nineteenth century. Although he did not know the physical basis for heredity, Mendel observed that organisms inherit traits via discrete units of inheritance, now called genes.
Modern genetics has expanded beyond inheritance. It studies the way genes work.
DNA[change | change source]
Living things are made of millions of tiny self-contained components called cells. Inside each cell are long and complex molecules called deoxyribonucleic acid, known for short as DNA. Some DNA stores information for making proteins. The bits of DNA which do this are known as genes. People look different from each other mainly because they have different versions of the human set of genes.
However, a large part of DNA (more than 98% for humans) is non-coding DNA. These sections do not serve as patterns for protein sequences. What it does is code for important non-protein information. Examples are various important RNA molecules, and "scaffolding" bits and pieces like centromeres and telomeres.
Every cell in the same living thing has the same DNA, but only some of it is used in each cell. For instance, some genes that tell how to make parts of the liver are switched off in the brain. What genes are used can also change over time. For instance, a lot of genes are used by a child early in pregnancy that are not used later.
A person has two copies of each gene, one from their mother, and one from their father. There can be several types of a single gene, which give different instructions: one version might cause a person to have blue eyes, another might cause them to have brown. These different versions are known as alleles of the gene.
Since a living thing has two copies of each gene, it can have two different alleles of it at the same time. Often, one allele will be dominant, meaning that the living thing looks and acts as if it had only that one allele. The unexpressed allele is called recessive. In other cases, you end up with something in between the two possibilities. In that case, the two alleles are called co-dominant.
Most of the characteristics that you can see in a living thing have more than one gene which influences them. And many genes have multiple effects on the body, because their function will not have the same effect in each tissue. The multiple effects of a single gene is called pleiotropism. The whole set of genes is called the genotype, and the total effect of genes on the body is called the phenotype. These are key terms in genetics.
History of genetics[change | change source]
Pre-Mendelian ideas[change | change source]
We know that man started breeding domestic animals from early times, probably before the invention of agriculture. We do not know when heredity was first appreciated as a scientific problem. The Greeks, and most obviously Aristotle, studied living things, and proposed ideas about reproduction and heredity.
Imre Festetics, who published work in German in the first part of the 19th century, was totally forgotten until recently. He described several rules of genetic inheritance in his work Die genetische Gesätze der Natur, 1819 (The genetic law of nature). His second law is the same as Mendel. In his third law, he developed the basic principles of mutation. None of the histories of genetics published in the 20th century mentions him.
Probably the most publicized idea before Mendel was that of Charles Darwin, whose idea of pangenesis had two parts. The first, that persistent hereditary units were passed on from one generation to another, was quite right. The second was his idea that they were replenished by 'gemmules' from the somatic (body) tissues. This was entirely wrong, and plays no part in science today. Darwin was right about one thing: whatever happens in evolution must happen by means of heredity, and so an accurate science of genetics is fundamental to the theory of evolution. This 'mating' between genetics and evolution took many years to organise. It resulted in the modern evolutionary synthesis.
Mendelian genetics[change | change source]
The basic rules of genetics were discovered by Imre Festetics, a landowner (1764–1847), and a monk named Gregor Mendel around 1865. For thousands of years people had noticed how some traits in parents are passed to their children. However, Mendel's work was different because he designed his experiments very carefully.
In his experiments, Mendel studied how traits were passed on in pea plants. He started his crosses with plants that bred true, and counted characters that were either/or in nature (either tall or short). He bred large numbers of plants, and expressed his results numerically. He used test crosses to reveal the presence and proportion of recessive characters.
Mendel explained the results of his experiment using two scientific laws:
- 1. Factors, later called genes, normally occur in pairs in ordinary body cells, yet separate during the formation of sex cells. These factors determine the organism's traits, and are inherited from its parents. When gametes are produced by meiosis, the two factors separate. A gamete only receives one or the other. This Mendel called the Law of segregation.
- 2. Alleles of different genes separate independently of one another when gametes are formed. This he called the Law of Independent Assortment. So Mendel thought that different traits are inherited independently of one another. We now know this is only true if the genes are not on the same chromosome, in which case they are not linked to each other.
Mendel's laws helped explain the results he observed in his pea plants. Later, geneticists discovered that his laws were also true for other living things, even humans. Mendel's findings from his work on the garden pea plants helped to establish the field of genetics. His contributions were not limited to the basic rules that he discovered. Mendel's care towards controlling experiment conditions along with his attention to his numerical results set a standard for future experiments. Over the years, scientists have changed and improved Mendel's ideas. However, the science of genetics would not be possible today without the early work of Gregor Mendel.
Between Mendel and modern genetics[change | change source]
Between Mendel's work and 1900 the foundations of cytology, the study of cells, was developed. The facts discovered about the nucleus and cell division were essential for Mendel's work to be properly understood.
- 1832: Barthélémy Dumortier, the first to observe cell division in a multicellular organism.
- 1841, 1852: Robert Remak (1815–1865), a Jewish Polish–German physiologist, was the first person to state the foundation of cell biology: that cells only derive from other cells. This was later popularized by the German doctor Rudolf Virchow (1821–1902), who used the famous phrase omnis cellula e cellula, meaning, all cells from other cells.
- 1865: Gregor Mendel's paper, Experiments on plant hybridization was published.
- 1876: Meiosis was discovered and described for the first time in sea urchin eggs, by German biologist Oscar Hertwig (1849–1922).
- 1878–1888: Walther Flemming and Eduard Strasburger describe chromosome behaviour during mitosis.
- 1883: Meiosis was described at the level of chromosomes, by Belgian zoologist Edouard van Beneden (1846–1910), in Ascaris (roundworm) eggs.
- 1883: German zoologist Wilhelm Roux (1850–1924) realised the significance of the linear structure of chromosomes. Their splitting into two equal longitudinal halves meant each daughter cell got the same chromosome complement. Therefore, chromosomes were the bearers of heredity.
- 1889: Dutch botanist Hugo de Vries suggests that "inheritance of specific traits in organisms comes in particles", naming such particles (pan)genes.
- 1890: The significance of meiosis for reproduction and inheritance was described in 1890 by German biologist August Weismann (1834–1914). He noted that two cell divisions were necessary to turn one diploid cell into four haploid cells if the number of chromosomes was to be maintained.
- 1902–1904: Theodor Boveri (1862–1915), a German biologist, in a series of papers, drew attention to the correspondence between the behaviour of chromosomes and the results obtained by Mendel. He said that chromosomes were "independent entities which keep their independence even in the resting nucleus... What comes out of the nucleus is what goes into it".
- 1903: Walter Sutton suggested that chromosomes, which segregate in a Mendelian fashion, are hereditary units. Edmund B. Wilson (1856–1939), Sutton's teacher, was the author of one of the most famous text-books in biology. Wilson called this idea the Sutton–Boveri hypothesis.
At this point, discoveries in cytology merged with the rediscovered ideas of Mendel to make a fusion called cytogenetics, (cyto = cell; genetics = heredity) which has continued to the present day.
Rediscovery of Mendel's work[change | change source]
During the 1890s several biologists began doing experiments on breeding. and soon Mendel's results were duplicated, even before his papers were read. Carl Correns and Hugo de Vries were the main rediscoverers of Mendel's writings and laws. Both acknowledged Mendel's priority, although it is probable that de Vries did not understand his own results until after reading Mendel. Though Erich von Tschermak was originally also credited with rediscovery, this is no longer accepted because he did not understand Mendel's laws. Though de Vries later lost interest in Mendelism, other biologists built genetics into a science.
Mendel's results were replicated, and genetic linkage soon worked out. William Bateson perhaps did the most in the early days to publicise Mendel's theory. The word genetics, and other terminology, originated with Bateson.
Mendel's experimental results were later the object of some debate. Fisher analysed the results of the F2 (second filial) ratio and found them to be implausibly close to the exact ratio of 3 to 1. It is sometimes suggested that Mendel may have censored his results, and that his seven traits each occur on a separate chromosome pair, an extremely unlikely occurrence if they were chosen at random. In fact, the genes Mendel studied occurred in only four linkage groups, and only one gene pair (out of 21 possible) is close enough to show deviation from independent assortment; this is not a pair that Mendel studied.
Tools of genetics[change | change source]
Mutations[change | change source]
During the process of DNA replication, errors sometimes occur. These errors, called mutations, can have an effect on the phenotype of an organism. In turn, that usually has an effect on the organism's fitness, its ability to live and reproduce successfully.
Error rates are usually very low—1 error in every 10–100 million bases—due to the "proofreading" ability of DNA polymerases. Error rates are a thousandfold higher in many viruses. Because they rely on DNA and RNA polymerases which lack proofreading ability, they get higher mutation rates.
Processes that increase the rate of changes in DNA are called mutagenic. Mutagenic chemicals increase errors in DNA replication, often by interfering with the structure of base-pairing, while UV radiation induces mutations by causing damage to the DNA structure. Chemical damage to DNA occurs naturally as well, and cells use DNA repair mechanisms to repair mismatches and breaks in DNA—nevertheless, the repair sometimes fails to return the DNA to its original sequence.
In organisms which use chromosomal crossovers to exchange DNA and recombine genes, errors in alignment during meiosis can also cause mutations. Errors in crossover are especially likely when similar sequences cause partner chromosomes to adopt a mistaken alignment; this makes some regions in genomes more prone to mutating in this way. These errors create large structural changes in DNA sequence—duplications, inversions or deletions of entire regions, or the accidental exchanging of whole parts between different chromosomes (called translocation).
Punnett squares[change | change source]
If B represents the allele for having black hair and b represents the allele for having white hair, the offspring of two Bb parents would have a 25% probability of having two white hair alleles (bb), 50% of having one of each (Bb), and 25% of having only black hair alleles (BB).
Pedigree chart[change | change source]
Geneticists (biologists who study genetics) use pedigree charts to record traits of people in a family. Using these charts, geneticists can study how a trait is inherited from person to person.
Geneticists can also use pedigree charts to predict how traits will be passed to future children in a family. For instance, genetic counselors are professionals who work with families who might be affected by genetic diseases. As part of their job, they create pedigree charts for the family, which can be used to study how the disease might be inherited.
Twin studies[change | change source]
Since human beings are not bred experimentally, human genetics must be studied by other means. One recent way is by studying the human genome. Another way, older by many years, is to study twins. Identical twins are natural clones. They carry the same genes, they may be used to investigate how much heredity contributes to individual people. Studies with twins have been quite interesting. If we make a list of characteristic traits, we find that they vary in how much they owe to heredity. For example:
- Eye colour: entirely inherited
- Weight, height: partly inherited, partly environmental
- Which language a person speaks: entirely environmental.
The way the studies are done is like this. Take a group of identical twins and a group of fraternal twins. Measure them for various traits. Do a statistical analysis (such as analysis of variance). This tells you to what extent the trait is inherited. Those traits which are partly inherited will be significantly more similar in identical twins. Studies like this may be carried further, by comparing identical twins brought up together with identical twins brought up in different circumstances. That gives a handle on how much circumstances can alter the outcomes of genetically identical people.
The person who first did twin studies was Francis Galton, Darwin's half-cousin, who was a founder of statistics. His method was to trace twins through their life-history, making many kinds of measurement. Unfortunately, though he knew about mono and dizygotic twins, he did not appreciate the real genetic difference. Twin studies of the modern kind did not appear until the 1920s.
Genetics of prokaryotes and viruses[change | change source]
The genetics of bacteria, archaea and viruses is a major field of research. Bacteria mostly divide by asexual cell division, but do have a kind of sex by horizontal gene transfer. Bacterial conjugation, transduction and transformation are their methods. In addition, the complete DNA sequence of many bacteria, archaea and viruses is now known.
Although many bacteria were given generic and specific names, like Staphylococcus aureus, the whole idea of a species is rather meaningless for an organism which does not have sexes and crossing-over of chromosomes. Instead, these organisms have strains, and that is how they are identified in the laboratory.
Genes and development[change | change source]
Gene expression[change | change source]
Gene expression is how the heritable information in a gene, the sequence of DNA base pairs, is made into a functional gene product, such as protein or RNA. The basic idea is that DNA is transcribed into RNA, which is then translated into proteins. Proteins make many of the structures and all the enzymes in a cell or organism.
Several steps in the gene expression process may be modulated (tuned). This includes both the transcription and translation stages, and the final folded state of a protein. Gene regulation switches genes on and off, and so controls cell differentiation, and morphogenesis. Gene regulation may also serve as a basis for evolutionary change: control of the timing, location, and amount of gene expression can have a profound effect on the development of the organism. The expression of a gene may vary a lot in different tissues. This is called pleiotropism, a widespread phenomenon in genetics.
Alternative splicing is a modern discovery of great importance. It is a process where from a single gene a large number of variant proteins can be assembled. One particular Drosophila gene (DSCAM) can be alternatively spliced into 38,000 different mRNA molecules.
Epigenetics & control of development[change | change source]
Epigenetics is the study of changes in gene activity which are not caused by changes in the DNA sequence. It is the study of gene expression, the way genes bring about their phenotypic effects.
These changes in gene activity may stay for the remainder of the cell's life and may also last for many generations of cells, through cell divisions. However, there is no change in the underlying DNA sequence of the organism. Instead, non-hereditary factors cause the organism's genes to behave (express themselves) differently.
Hox genes are a complex of genes whose proteins bind to the regulatory regions of target genes. The target genes then activate or repress cell processes to direct the final development of the organism.
Extranuclear inheritance[change | change source]
There are some kinds of heredity which happen outside the cell nucleus. Normal inheritance is from both parents via the chromosomes in the nucleus of a fertilised egg cell. There are some kinds of inheritance other than this.
Organelle heredity[change | change source]
Mitochondria and chloroplasts carry some DNA of their own. Their make-up is decided by genes in the chromosomes and genes in the organelle. Carl Correns discovered an example in 1908. The four o'clock plant, Mirabilis jalapa, has leaves which may be white, green or variegated. Correns discovered the pollen had no influence on this inheritance. The colour is decided by genes in the chloroplasts.
Infectious heredity[change | change source]
Maternal effect[change | change source]
In this case nuclear genes in the female gamete are transcribed. The products accumulate in the egg cytoplasm, and have an effect on the early development of the fertilised egg. The coiling of a snail, Limnaea peregra, is determined like this. Right-handed shells are genotypes Dd or dd, while left-handed shells are dd.
The most important example of maternal effect is in Drosophila melanogaster. The protein product maternal-effect genes activate other genes, which in turn activate still more genes. This work won the Nobel Prize in Physiology or Medicine for 1995.
Aspects of modern genetics[change | change source]
- Alternative splicing, where one gene codes for a variety of related protein products.
- Genomics, the sequence and analysis the function and structure of genomes.
- Genetic engineering, the changing of an organism's genome using biotechnology.
- Mobile genetic elements, types of DNA which can change position in the genome.
- Horizontal gene transfer, where an organism gets genetic material from another organism without being the offspring of that organism.
- Epigenetics, the study of changes in gene activity which are not caused by changes in the DNA sequence.
- CRISPR: In 2012, Jennifer Doudna and Emmanuelle Charpentier suggested that CRISPR-Cas9 (enzymes from bacteria which control microbial immunity) could be used to edit genomes. This has been called one of the most significant discoveries in the history of biology. The two scientists shared the 2020 Nobel Prize in Chemistry.
Genetics of human behaviour[change | change source]
Many well-known disorders of human behaviour have a genetic component. This means that their inheritance partly causes the behaviour, or makes it more likely the problem would occur. Examples include:
Also, normal behaviour is also heavily influenced by heredity:
Related pages[change | change source]
References[change | change source]
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- King R.C. Stansfield W.D. & Mulligan. P.K. 2006. A dictionary of genetics, 7th ed. Oxford.
- Griffiths A.J.H. et al (eds) 2000. An introduction to genetic analysis. 7th ed, Freeman, New York. ISBN 0-7167-3520-2 
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- The earlier ideas of Imre Festetics were completely forgotten for many years.
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- Some types of living things only have one parent. Also, some living things have only one copy of each gene (bacteria, for example) and some plants have an extra set. Some genes come from only one parent, like genes on the human Y chromosome which is passed only from father to son.
- This applies only to eukaryotes and not, for example, to bacteria.
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- Wilson E.B. 1896; 1900; 1925. The cell. Macmillan, London. The third edition ran to 1232 pages.
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- By "DNA sequence" we mean the sequence of nucleotide base pairs in an exon, which is the part of a gene which determines the sequence of amino acids in the coded protein.
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- Pollack, Andrew (May 11, 2015). "Jennifer Doudna, a pioneer who helped simplify genome editing". The New York Times. Retrieved May 12, 2015.
- Jennifer A. Doudna and Samuel H. Sternberg. 2017. A crack in creation: gene editing and the unthinkable power to control evolution. New York: Houghton Mifflin Harcourt.
- Plomin, Robert et al 2001. Behavioral genetics. 4th ed, New York: Worth, Overview, 1–5. ISBN 0-7167-5159-3
- Ghost in your genes. NOVA, PBS
Standard works[change | change source]
- Alberts B, Bray D, Hopkin K, Johnson A, Lewis J, Raff M, Roberts K, Walter P. 2013. Essential cell biology, 4th Edition. Garland Science. ISBN 978-1-317-80627-1.
- Griffiths A.J.H. & others 2000. An introduction to genetic analysis. 7th ed, Freeman, New York. ISBN 0-7167-3520-2 
- Hartl D. & Jones E. 2005. Genetics: analysis of genes and genomes. 6th ed, Jones & Bartlett. ISBN 0-7637-1511-5.
- King R.C; Mulligan P.K. & Stansfield W.D. 2013. A dictionary of genetics. 8th ed, Oxford University Press. ISBN 978-0-19-976644-4
- Klug, William S. et al 2012. Concepts of genetics. 10th ed, Pearson. ISBN 0-321-79578-4.
- Lodish H, Berk A, Zipursky LS, Matsudaira P, Baltimore D, Darnell J(2000. Molecular Cell Biology. 4th ed, New York: Scientific American Books. ISBN 978-0-7167-3136-8
Works on genetic manipulation[change | change source]
- Jennifer A. Doudna and Samuel H. Sternberg. 2017. A Crack in Creation: gene editing and the unthinkable power to control evolution. Houghton Mifflin Harcourt.
- Carey, Nessa 2019. Hacking the code of life: how gene editing will write our futures. London: Icon Books. ISBN 978-1-78578-625-9.