Queen Isabella of Armenia (died c. 1252) ruled the Armenian Kingdom of Cilicia 1219–1252. She was the daughter of Leo II of Armenia and Sybilla of Lusignan (daughter of Amalric I of Cyprus). Leo named Isabella as his heir.
- Leo III (d. 1289)
- Thoros (d. 1266),
- Sibylle (d. 1290), who married Bohemund VI of Antioch
- Euphemie (d. 1309), who married to Julien Grenier, Lord of Sidon
- Rita of Armenia
- Maria of Armenia, who married Guy d'Ibelin
| Queen of Armenia