She became the youngest-ever champion at the 1990 French Open at the age of 16. She was the dominant player in the women's game during 1991 and 1992, but in 1993, she was forced out of the sport for two years following an on-court attack in which a spectator stabbed her in the back with a knife. She enjoyed some success after returning to the tour in 1995, including a singles title at the Australian Open in 1996, but was unable to consistently reproduce her very best form.
Seles played her last professional match at the 2003 French Open, but her official retirement announcement was not issued until February 2008. She was a contestant on Dancing with the Stars in 2008.