Quetiapine

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Quetiapine
Quetiapine.svg
Quetiapine-from-xtal-3D-balls.png
Clinical data
Pronunciation/kwɪˈt.əpn/ kwi-TY-ə-peen
Trade namesSeroquel, Temprolide, others
AHFS/Drugs.comMonograph
MedlinePlusa698019
License data
Pregnancy
category
  • AU: B3
  • US: C (Risk not ruled out)
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability100%[2]
Protein binding83%[3]
MetabolismLiver via CYP3A4-catalysed sulfoxidation to its active metabolite norquetiapine (N-desalkylquetiapine)[1]
Elimination half-life7 hours (parent compound); 9–12 hours (active metabolite, norquetiapine)[3][4]
ExcretionKidney (73%), faeces (20%)[2][3][4][5]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard100.131.193 Edit this at Wikidata
Chemical and physical data
FormulaC21H25N3O2S
Molar mass383.5099 g/mol
3D model (JSmol)
Solubility in water3.29 mg/mL (20 °C)
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Quetiapine (better known as Seroquel) is an antipsychotic drug used to treat bipolar disorder and unipolar major depression, though it is used off-label for anxiety problems, Tourette syndrome and autism issues. The side effects of Quetiapine include fatigue, dry mouth and being sleepy. The medication is sometimes used for PTSD.

References[change | change source]

  1. Brunton, L; Chabner, B; Knollman, B (2010). Goodman and Gilman's The Pharmacological Basis of Therapeutics (12th ed.). McGraw Hill Professional. ISBN 978-0071624428.
  2. 2.0 2.1 "quetiapine (Rx) - Seroquel, Seroquel XR". Medscape Reference. WebMD. Archived from the original on 20 October 2013. Retrieved 11 October 2013.
  3. 3.0 3.1 3.2 "Quetiapine 25 mg film-coated tablets - Summary of Product Characteristics". electronic Medicines Compendium. Sandoz. January 2013. Archived from the original on 20 October 2013. Retrieved 20 October 2013.
  4. 4.0 4.1 Truven Health Analytics, Inc. DrugPoint System (Internet) [cited 2013 Sep 18]. Greenwood Village, CO: Thomsen Healthcare; 2013.
  5. "QUETIAPINE FUMARATE tablet QUETIAPINE FUMARATE (quetiapine fumarate ) tablet [Ascend Laboratories, LLC]". DailyMed. Ascend Laboratories, LLC. October 2013. Archived from the original on 2 December 2013. Retrieved 26 November 2013.