|Trade names||Largactil, Thorazine, many others|
|Oral (tablets and syrup available), rectal, IM, IV infusion|
|Bioavailability||10–80% (Oral; large interindividual variation)|
|Metabolism||Liver, mostly CYP2D6-mediated|
|Elimination half-life||30 hours|
|Excretion||Urine (43–65% in 24 hrs)|
|Chemical and physical data|
|Molar mass||318.86 g/mol (free base)|
355.33 g/mol (hydrochloride)
|3D model (JSmol)|
Chlorpromazine, also known by its trade name Thorazine, is an antipsychotic drug. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting. Chlorpromazine was developed in 1950, making it the oldest antipsychotic drug.
References[change | change source]
- ↑ 1.0 1.1 1.2 1.3 "PRODUCT INFORMATION LARGACTIL" (PDF). TGA eBusiness Services. Sanofi Aventis Pty Ltd. 28 August 2012. Archived from the original on 30 March 2017. Retrieved 8 December 2013.
- ↑ "ChlorproMAZINE Monograph for Professionals". Drugs.com. Retrieved 2022-09-22.
- ↑ López-Muñoz, Francisco; Alamo, Cecilio; cuenca, Eduardo; Shen, Winston; Clervoy, Patrick; Rubio, Gabriel (2005-07-01). "History of the Discovery and Clinical Introduction of Chlorpromazine". Annals of Clinical Psychiatry. 17 (3): 113–135. doi:10.1080/10401230591002002. ISSN 1040-1237. PMID 16433053.