Uterine sarcoma
The uterine sarcomas form a group of malignant tumors that grow out from the smooth muscle or connective tissue of the uterus.
Signs and symptoms[change | change source]
Uterine sarcomas and fibroids are alike. Both have an increased uterine size. Abdominal pain and vaginal bleeding happen in both. It can be difficult to tell them apart.[1] Unusual vaginal bleeding may be a sign of uterine sarcoma. Other signs of a uterine sarcoma can be pelvic pain, pressure, and unusual discharge. If a uterus is larger than normal this could also be a sign. There is no special test to detect a uterine sarcoma. A Pap smear is a screening test for cervical cancer and not designed to detect uterine sarcoma.
Diagnosis[change | change source]
MRI is able to find the differences between leiomyomas and uterine sarcomas.[1] Investigations by the physician include imaging (ultrasound, CAT scan, MRI) and, if possible, obtaining a tissue diagnosis by biopsy, hysteroscopy, or D&C. Ultimately the diagnosis is established by the histologic examination of the specimen. Typically malignant lesions have >10 mitosis per high power field. In contrast, a uterine leiomyoma as a benign lesion would have < 5 mitoses per high power field.
Management[change | change source]
Therapy is based on staging and patient condition. Surgery is the mainstay of therapy if feasible involving total abdominal hysterectomy with bilateral salpingo-oophorectomy. Other approaches include radiation therapy, chemotherapy, and hormonal therapy.
Prognosis is relatively poor.[2]
Epidemiology[change | change source]
Uterine sarcoma is rare. Out of all malignancies of the uterine body only about 4% will be uterine sarcomas.[3] Generally, the cause of the lesion is not known, however, patients with a history of pelvic radiation are at higher risk. Most tumors occur after menopause. Women who take long-term tamoxifen are at higher risk.[4]
Related articles[change | change source]
References[change | change source]
- ↑ 1.0 1.1 Smith J, Zawaideh JP, Sahin H, Freeman S, Bolton H, Addley HC (September 2021). "Differentiating uterine sarcoma from leiomyoma: BET1T2ER Check!". Br J Radiol. 94 (1125): 20201332. doi:10.1259/bjr.20201332. PMC 9327746. PMID 33684303. S2CID 232159216.
- ↑ Gadducci A, Cosio S, Romanini A, Genazzani AR (February 2008). "The management of patients with uterine sarcoma: a debated clinical challenge". Crit. Rev. Oncol. Hematol. 65 (2): 129–42. doi:10.1016/j.critrevonc.2007.06.011. PMID 17706430.
- ↑ [1] Archived 2010-05-14 at the Wayback Machine American Cancer Society information, accessed 03-11-2006
- ↑ [2] National Cancer Institute information, accessed 03-11-2006