Valproate

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Valproate or VPA is a drug with the different forms, valproic acid, Sodium Valproate and Valproate semisodium. It is mostly used to treat epilepsy and bipolar disorder. It is also used to prevent migraines.[1] It is useful to prevent some kinds of seizures. It can be given intravenously or by mouth.

Common side effects of this medication are sleepiness, dry mouth, weakness, vomiting and nausea. Serious side effects can include liver problems, pancreatitis and an increased suicide risk. Valproate is known to cause birth defects and miscarriages in pregnant women who use the medicine,so it is not recommended for women who are pregnant or able to become pregnant to take Valproate.

Overdose and poisoning[change | change source]

Too much valproic acid can result in sleepiness, shaking, near unconsciousness, shallow breathing, coma, metabolic acidosis, and death. Normal plasma valproic acid levels are in a range of 20–100 mg/l during managed treatment, but may reach 150–1500 mg/l after serious poisoning.[2]

Brand names[change | change source]

Brand names of valproic acid[change | change source]

Branded products include:

Brand names of sodium valproate[change | change source]

Portugal[change | change source]
  • Tablets – Diplexil-R by Bial.
United States[change | change source]
Australia[change | change source]
New Zealand[change | change source]

All the above formulations are Pharmac-subsidised.[3]

UK[change | change source]
  • Depakote Tablets (as in USA)
  • Tablets – Orlept by Wockhardt and Epilim by Sanofi
  • Oral solution – Orlept Sugar Free by Wockhardt and Epilim by Sanofi
  • Syrup – Epilim by Sanofi-Aventis
  • Intravenous injection – Epilim Intravenous by Sanofi
  • Extended release tablets – Epilim Chrono by Sanofi is a combination of sodium valproate and valproic acid in a 2.3:1 ratio.
  • Enteric-coated tablets – Epilim EC200 by Sanofi is a 200-mg sodium valproate enteric-coated tablet.
UK only[change | change source]
  • Capsules – Episenta prolonged release by Beacon
  • Sachets – Episenta prolonged release by Beacon
  • Intravenous solution for injection – Episenta solution for injection by Beacon
Germany, Switzerland, Norway, Finland, Sweden[change | change source]
  • Tablets – Orfiril by Desitin Pharmaceuticals
  • Intravenous injection – Orfiril IV by Desitin Pharmaceuticals
South Africa[change | change source]
  • Syrup – Convulex by Byk Madaus
  • Tablets – Epilim by Sanofi-synthelabo
Malaysia[change | change source]
  • Tablets – Epilim by Sanofi-Aventis
Romania[change | change source]
  • Companies are SANOFI-AVENTIS FRANCE, GEROT PHARMAZEUTIKA GMBH and DESITIN ARZNEIMITTEL GMBH
  • Types are Syrup, Extended release mini tablets, Gastric resistant coated tablets, Gastric resistant soft capsules, Extended release capsules, Extended release tablets and Extended release coated tablets
Canada[change | change source]
Japan[change | change source]
  • Tablets – Depakene by Kyowa Hakko Kirin
  • Extended release tablets – Depakene-R by Kyowa Hakko Kogyo and Selenica-R by Kowa
  • Syrup – Depakene by Kyowa Hakko Kogyo
Europe[change | change source]

In much of Europe, Dépakine and Depakine Chrono (tablets) are equivalent to Epilim and Epilim Chrono above.

Taiwan[change | change source]
Israel[change | change source]
  • Depalept (equivalent of Epilim)
  • Depalept Chrono (extended release tablets; equivalent of Epilim Chrono)
India, Russia and CIS countries[change | change source]
  • Valprol CR by Intas Pharmaceutical (India)
  • Encorate Chrono by Sun Pharmaceutical (India)
  • Serven Chrono by Leeven APL Biotech (India)

Brand names of valproate semisodium[change | change source]

  • Brazil – Depakote by Abbott Laboratories and Torval CR by Torrent do Brasil
  • Canada – Epival by Abbott Laboratories
  • Mexico – Epival and Epival ER (extended release) by Abbott Laboratories
  • United Kingdom – Depakote (for psychiatric conditions) and Epilim (for epilepsy) by Sanofi-Aventis and generics
  • United States – Depakote and Depakote ER (extended release) by Abbott Laboratories and generics
  • India – Valance and Valance OD by Abbott Healthcare Pvt Ltd, Divalid ER by Linux laboratories Pvt Ltd, Valex ER by Sigmund Promedica, Dicorate by Sun Pharma
  • Germany – Ergenyl Chrono by Sanofi-Aventis and generics
  • Chile – Valcote and Valcote ER by Abbott Laboratories
  • France and other European countries — Depakote
  • Peru – Divalprax by AC Farma Laboratories
  • China – Diprate OD


References[change | change source]

  1. "Valproic Acid". Drugs.com. Retrieved Mar 22, 2016.
  2. Sztajnkrycer MD (2002). "Valproic acid toxicity: overview and management". J. Toxicol. Clin. Toxicol. 40 (6): 789–801. doi:10.1081/CLT-120014645. PMID 12475192. 
  3. "Sodium valproate -- Pharmaceutical Schedule". Pharmaceutical Management Agency. Archived from the original on 4 March 2016. Retrieved 22 June 2014.