An intron is a non-coding sequence in a gene.
It is any nucleotide sequence within a gene that is removed by RNA splicing to get the final RNA product of a gene. The term intron refers to both the DNA sequence within a gene, and the corresponding sequence in RNA transcripts.
Introns are in the genes of most organisms and many viruses. They can be in a wide range of genes, including those that generate proteins, ribosomal RNA (rRNA), and transfer RNA (tRNA). RNA splicing takes place after transcription and before translation.
- Introns: parts of a gene which are discarded: non-working bits.
- Exons: parts of a gene which are expressed: bits of a gene which code for amino-acid sequences in a protein.
Biological meaning[change | change source]
Recent studies of entire eukaryotic genomes have now shown that the lengths and density (introns/gene) of introns varies considerably between related species. There are four or five different kinds of intron. Some introns represent mobile genetic elements (transposons).
Alternative splicing of introns within a gene allows a variety of protein isoforms from a single gene. Thus multiple related proteins can be generated from a single gene and a single precursor mRNA transcript. The control of alternative RNA splicing is performed by complex network of signalling molecules. In humans, ~95% of genes with more than one exon are alternatively spliced.
References[change | change source]
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